RNase L Antibody (2E9.2G5): sc-23955
- RNase L Antibody (2E9.2G5) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against purified recombinant human RNase L
- recommended for detection of RNase L of human origin by WB, IP, IF and IHC(P)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RNase L Antibody (2E9.2G5) for WB and IHC(P) applications. These reagents are now offered in bundles with RNase L Antibody (2E9.2G5) (see ordering information below).
QUICK LINKS
SEE ALSO...
RNase L Antibody (2E9.2G5) is a mouse monoclonal IgG1 antibody that detects RNase L in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. RNase L plays a crucial role in the antiviral and antiproliferative activities of interferons by encoding a component of the interferon-regulated 2-5A system, which is essential for the degradation of viral RNA and the regulation of cellular growth. RNase L (2E9.2G5) antibody enhances detection of protein responses to interferon treatment, including elevated levels of RNase L and synthetases that generate 5-prime-triphosphorylated, 2-prime,5-prime-oligoadenylates (2-5A) from ATP. The 2-5A system is integral to the immune response, and defects in the RNase L gene can lead to compromised immunity against viral infections and increased risk of cancer, particularly prostate cancer, where mutations have been linked to hereditary predisposition. Anti-RNase L antibody (2E9.2G5) serves as an invaluable tool for researchers studying viral defense and cancer biology mechanisms, providing insights into functional dynamics of this critical protein.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RNase L Antibody (2E9.2G5) References:
- Pathologic effects of RNase-L dysregulation in immunity and proliferative control. | Ezelle, HJ. and Hassel, BA. 2012. Front Biosci (Schol Ed). 4: 767-86. PMID: 22202089
- RNase-L control of cellular mRNAs: roles in biologic functions and mechanisms of substrate targeting. | Brennan-Laun, SE., et al. 2014. J Interferon Cytokine Res. 34: 275-88. PMID: 24697205
- The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response. | Ezelle, HJ., et al. 2016. Int J Mol Sci. 17: PMID: 26760998
- Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents. | Hwang, J., et al. 2022. Bioorg Med Chem. 58: 116653. PMID: 35152173
- RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus. | Burke, JM., et al. 2022. PLoS Pathog. 18: e1010930. PMID: 36318584
- Rotavirus NSP1 Subverts the Antiviral Oligoadenylate Synthetase-RNase L Pathway by Inducing RNase L Degradation. | Dai, J., et al. 2022. mBio. 13: e0299522. PMID: 36413023
- Regulation of ribonucleoprotein condensates by RNase L during viral infection. | Burke, JM. 2023. Wiley Interdiscip Rev RNA. 14: e1770. PMID: 36479619
- Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children. | Lee, D., et al. 2023. Science. 379: eabo3627. PMID: 36538032
- Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L. | Xi, J., et al. 2024. Cell Rep. 43: 113998. PMID: 38551960
- RNase L-induced bodies sequester subgenomic flavivirus RNAs to promote viral RNA decay. | Watkins, JM. and Burke, JM. 2024. Cell Rep. 43: 114694. PMID: 39196777
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RNase L Antibody (2E9.2G5) | sc-23955 | 200 µg/ml | $322.00 | |||
RNase L Antibody (2E9.2G5): m-IgG Fc BP-HRP Bundle | sc-536694 | 200 µg Ab; 10 µg BP | $361.00 | |||
RNase L Antibody (2E9.2G5): m-IgGκ BP-HRP Bundle | sc-533854 | 200 µg Ab; 40 µg BP | $361.00 | |||
RNase L Antibody (2E9.2G5): m-IgG1 BP-HRP Bundle | sc-544770 | 200 µg Ab; 20 µg BP | $361.00 |