PREP-1 Antibody (H-1): sc-55471
- PREP-1 Antibody (H-1) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 15-436 mapping at the N-terminus of PREP-1 of human origin
- recommended for detection of PREP-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PREP-1 Antibody (H-1) for WB applications. These reagents are now offered in bundles with PREP-1 Antibody (H-1) (see ordering information below).
PREP-1 Antibody (H-1) is a mouse monoclonal IgG2a antibody that detects PREP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PREP-1, also known as UEF3 or p64, is a crucial DNA-binding protein that plays a significant role in gene transcription regulation, particularly in conjunction with Pbx proteins. PREP-1 forms stable complexes with these proteins, enhancing the transcriptional activity of AP-1 containing promoters, which is vital for processes such as cell proliferation and differentiation. PREP-1 interaction with Pbx proteins is essential for the modulation of various target genes, including the urokinase gene, which is involved in extracellular matrix remodeling and cell migration. Understanding PREP-1 function and interactions is important for elucidating the molecular mechanisms underlying various biological processes and diseases, including leukemias where these pathways may be dysregulated. Anti-PREP-1 antibody (H-1) serves as an invaluable tool for researchers studying gene regulation and cellular signaling pathways.
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PREP-1 Antibody (H-1) References:
- Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis. | Dardaei, L., et al. 2014. Proc Natl Acad Sci U S A. 111: E896-905. PMID: 24578510
- Prep1 (pKnox1) regulates mouse embryonic HSC cycling and self-renewal affecting the Stat1-Sca1 IFN-dependent pathway. | Modica, L., et al. 2014. PLoS One. 9: e107916. PMID: 25233378
- The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability. | Lorenzo, V., et al. 2016. Mol Biotechnol. 58: 328-39. PMID: 26979610
- Prep1 prevents premature adipogenesis of mesenchymal progenitors. | Maroni, G., et al. 2017. Sci Rep. 7: 15573. PMID: 29138456
- Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling. | Ricci, S., et al. 2018. Mol Neurobiol. 55: 6801-6815. PMID: 29349576
- PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry. | Palmigiano, A., et al. 2018. Sci Rep. 8: 3198. PMID: 29453404
- Prep1 (pKnox1) transcription factor contributes to pubertal mammary gland branching morphogenesis. | Sicouri, L., et al. 2018. Int J Dev Biol. 62: 827-836. PMID: 30604852
- The Role of Prep1 in the Regulation of Mesenchymal Stromal Cells. | Maroni, G., et al. 2019. Int J Mol Sci. 20: PMID: 31349607
- Interleukin 6 reduces vascular smooth muscle cell apoptosis via Prep1 and is associated with aging. | Cimmino, I., et al. 2021. FASEB J. 35: e21989. PMID: 34679197
- Resveratrol Improves Endothelial Function by A PREP1-Mediated Pathway in Mouse Aortic Endothelial Cells. | Cabaro, S., et al. 2023. Int J Mol Sci. 24: PMID: 37569266
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PREP-1 Antibody (H-1) | sc-55471 | 200 µg/ml | $322.00 | |||
PREP-1 Antibody (H-1): m-IgG Fc BP-HRP Bundle | sc-537042 | 200 µg Ab; 10 µg BP | $361.00 | |||
PREP-1 Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-534226 | 200 µg Ab; 40 µg BP | $361.00 |