Date published: 2025-11-22

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PREP Inhibitors

PREP inhibitors belong to a distinct chemical class that has garnered significant attention due to their unique mechanism of action and potential impact on specific biological processes. These inhibitors are designed to selectively target and modulate the activity of prolyl endopeptidase (PREP), a proteolytic enzyme found within cells. PREP plays a crucial role in the cleavage of peptide bonds involving proline residues, thereby influencing the processing and degradation of various peptides and proteins. The inhibitors of this class are meticulously crafted to interact with the active site of PREP, impeding its enzymatic function. By doing so, they have the capacity to perturb the intricate network of peptide metabolism and signaling pathways that PREP regulates. The structural attributes of PREP inhibitors facilitate their binding to the enzyme's catalytic pocket, obstructing substrate access and enzymatic turnover. This class of inhibitors encompasses a diverse range of chemical entities, each characterized by specific molecular features that facilitate effective binding and inhibition. Researchers continue to investigate the potential physiological implications of modulating PREP activity through these inhibitors, shedding light on the broader biochemical and cellular consequences of targeting this enzyme's function.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Z-Prolyl-prolinal

86925-97-5sc-201285
sc-201285A
5 mg
25 mg
$87.00
$326.00
5
(1)

Z-Prolyl-prolinal is a versatile compound that acts as a potent electrophile, engaging in selective nucleophilic attacks due to its unique structural features. Its reactivity is influenced by the presence of the proline moiety, which stabilizes transition states and enhances reaction rates. The compound exhibits distinct stereochemical properties, allowing for specific interactions with various nucleophiles. This specificity can lead to tailored reaction pathways, making it a valuable tool in synthetic chemistry.

Baicalein

491-67-8sc-200494
sc-200494A
sc-200494B
sc-200494C
10 mg
100 mg
500 mg
1 g
$31.00
$41.00
$159.00
$286.00
12
(1)

Baicalein is a flavonoid characterized by its ability to form strong hydrogen bonds and engage in π-π stacking interactions, which enhance its stability and solubility in various solvents. Its unique hydroxyl groups facilitate electron donation, making it an effective ligand in coordination chemistry. The compound's planar structure allows for efficient stacking with aromatic systems, influencing reaction kinetics and selectivity in complex organic transformations.

Baicalin

21967-41-9sc-204638
sc-204638A
sc-204638B
sc-204638C
1 mg
25 mg
1 g
5 g
$55.00
$110.00
$220.00
$260.00
4
(1)

Baicalin, a flavonoid glycoside, exhibits remarkable solubility due to its hydrophilic sugar moiety, which enhances its interaction with polar solvents. The compound's structural conformation allows for effective intramolecular hydrogen bonding, stabilizing its structure. Additionally, Baicalin's capacity to participate in redox reactions is influenced by its phenolic hydroxyl groups, which can donate electrons, thereby modulating reaction pathways and kinetics in various chemical environments.

pramiracetam

68497-62-1sc-280016
200 mg
$849.00
(0)

Pramiracetam, a racetam derivative, showcases unique lipophilicity, facilitating its passage through biological membranes. Its molecular structure allows for specific interactions with neurotransmitter receptors, potentially influencing synaptic plasticity. The compound's ability to form stable complexes with metal ions can alter its reactivity and stability in various environments. Furthermore, pramiracetam's kinetic profile suggests a rapid onset of action, driven by its efficient absorption and distribution in lipid-rich tissues.

Pikromycin

19721-56-3sc-391096
1 mg
$108.00
(0)

Pikromycin, a macrolide antibiotic, exhibits distinctive molecular interactions through its large lactone ring, which enhances its binding affinity to bacterial ribosomes. This interaction disrupts protein synthesis, showcasing a unique mechanism of action. The compound's hydrophobic regions contribute to its solubility in lipid environments, influencing its distribution and bioavailability. Additionally, its reaction kinetics reveal a notable stability under physiological conditions, allowing for prolonged activity against target organisms.

Y-29794 oxalate

129184-48-1sc-204408
sc-204408A
10 mg
50 mg
$203.00
$866.00
1
(0)

Y-29794 oxalate functions as a potent PREP, characterized by its unique reactivity as an acid halide. It engages in selective acylation reactions, facilitating the formation of stable intermediates. The compound's electron-withdrawing oxalate moiety enhances its electrophilicity, promoting rapid nucleophilic attack. Its distinct steric properties influence reaction pathways, leading to diverse product formation. Furthermore, Y-29794 oxalate demonstrates remarkable solubility in polar solvents, enhancing its reactivity in various chemical environments.