Pikromycin (CAS 19721-56-3)
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Pikromycin is utilized in biochemical applications focused on the study of macrolide antibiotics and their biosynthesis. Pikromycin is of interest due to its origin from Streptomyces bacteria, making it a model for understanding polyketide synthesis pathways. Some use Pikromycin to explore the enzymatic processes involved in the formation of macrolide structures, which are for the development of new antibiotics. The studies on Pikromycin also extend to investigating its mechanism of action, particularly how it interacts with bacterial ribosomes to inhibit protein synthesis. Pikromycin is in genetic engineering applications to study the genes, aiming to harness and modify these pathways for the production of novel compounds with potential industrial applications.
Pikromycin (CAS 19721-56-3) References
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- Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae. | Xue, Y. and Sherman, DH. 2001. Metab Eng. 3: 15-26. PMID: 11162229
- Structural basis for macrolactonization by the pikromycin thioesterase. | Akey, DL., et al. 2006. Nat Chem Biol. 2: 537-42. PMID: 16969372
- Total synthesis of narbonolide and biotransformation to pikromycin. | Venkatraman, L., et al. 2006. J Org Chem. 71: 9853-6. PMID: 17168607
- Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin. | Maharjan, S., et al. 2008. Biotechnol Lett. 30: 1621-6. PMID: 18421418
- Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin. | Hansen, DA., et al. 2013. J Am Chem Soc. 135: 11232-8. PMID: 23866020
- Effects of Sucrose, Phosphate, and Calcium Carbonate on the Production of Pikromycin from Streptomyces venezuelae. | Yi, JS., et al. 2015. J Microbiol Biotechnol. 25: 496-502. PMID: 25341465
- Heterologous expression of pikromycin biosynthetic gene cluster using Streptomyces artificial chromosome system. | Pyeon, HR., et al. 2017. Microb Cell Fact. 16: 96. PMID: 28569150
- Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides. | Hansen, DA., et al. 2017. J Am Chem Soc. 139: 13450-13455. PMID: 28836772
- Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. | Almutairi, MM., et al. 2017. Nucleic Acids Res. 45: 9573-9582. PMID: 28934499
- Production of pikromycin using branched chain amino acid catabolism in Streptomyces venezuelae ATCC 15439. | Yi, JS., et al. 2018. J Ind Microbiol Biotechnol. 45: 293-303. PMID: 29523997
- Growth and differentiation properties of pikromycin-producing Streptomyces venezuelae ATCC15439. | Kim, JE., et al. 2019. J Microbiol. 57: 388-395. PMID: 30721456
- Systems metabolic engineering of Streptomyces venezuelae for the enhanced production of pikromycin. | Cho, MK., et al. 2022. Biotechnol Bioeng. 119: 2250-2260. PMID: 35445397
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pikromycin, 1 mg | sc-391096 | 1 mg | $110.00 |