NVL Antibody (A-10): sc-393285

NVL Antibody (A-10) is a mouse monoclonal IgG2a antibody that detects NVL in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NVL, or nuclear valosin-containing protein-like, is a crucial member of the AAA ATPase family, consisting of 856 amino acids and playing a significant role in ATP-dependent nuclear processes and ribosome synthesis. NVL′s importance lies in its involvement in the regulation of essential cellular functions, particularly in the nucleus, where NVL facilitates the assembly and maturation of ribosomes, which are vital for protein synthesis. NVL exists in three alternatively spliced isoforms, each contributing to diverse functions, and is widely expressed across various tissues, with highest levels found in the pancreas, retina, heart, skeletal muscle, and placenta. NVL′s interaction with other proteins, including association with the proteasome and ubiquitinated substrates, underscores NVL′s critical role in maintaining cellular homeostasis and regulating the cell cycle. Anti-NVL antibody (A-10) is an invaluable tool for researchers exploring the intricate mechanisms of ribosome biogenesis and broader implications of ATPase activity in cellular processes.

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NVL Antibody (A-10) References:

1. [National disease management guidelines (NVL) for chronic CAD: What is new, what is particularly important?].  |  Werdan, K. 2016. Herz. 41: 537-60. PMID: 27586137
2. City-level SARS-CoV-2 sewage surveillance.  |  Yaniv, K., et al. 2021. Chemosphere. 283: 131194. PMID: 34467943
3. Prevalence of Patients with Uncontrolled Asthma Despite NVL/GINA Step 4/5 Treatment in Germany.  |  Bergmann, KC., et al. 2022. J Asthma Allergy. 15: 897-906. PMID: 35815115
4. NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations.  |  Drilon, A., et al. 2023. Cancer Discov. 13: 598-615. PMID: 36511802
5. Guidelines' recommendations for the treatment-resistant depression: A systematic review of their quality.  |  Gabriel, FC., et al. 2023. PLoS One. 18: e0281501. PMID: 36745622
6. Strategies to overcome resistance to ALK inhibitors in non-small cell lung cancer: a narrative review.  |  Desai, A. and Lovly, CM. 2023. Transl Lung Cancer Res. 12: 615-628. PMID: 37057106
7. Autoantibodies to nuclear valosin-containing protein-like protein: systemic sclerosis-specific antibodies revealed by in vitro human proteome.  |  Matsuda, KM., et al. 2024. Rheumatology (Oxford). 63: 2865-2873. PMID: 38290780
8. Washing Illness Away: A Systematic Review of the Impact of Nasal Irrigation and Spray on COVID-19.  |  Gandhi, K., et al. 2025. Laryngoscope. 135: 517-528. PMID: 39268910
9. NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations.  |  Lin, JJ., et al. 2024. Cancer Discov. 14: 2367-2386. PMID: 39269178
10. NVL: a new member of the AAA family of ATPases localized to the nucleus.  |  Germain-Lee, EL., et al. 1997. Genomics. 44: 22-34. PMID: 9286697

The preferred NVL antibody is NVL Antibody (G-10): sc-393047.