NTR1 Antibody (G-9): sc-393205

NTR1 Antibody (G-9) is a mouse monoclonal IgG2b antibody that detects neurotensin receptor 1 (NTR1) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NTR1 plays a crucial role in mediating the effects of neurotensin, a neuropeptide involved in numerous physiological processes such as pain modulation, regulation of blood pressure, and control of gastrointestinal motility. NTR1 is primarily located in the central nervous system and peripheral tissues, where activation can lead to significant intracellular signaling cascades that influence various biological responses. Notably, NTR1 interacts with G proteins, including Gq, Gi/o, and Gs, which are essential for transducing signals that can affect neuronal excitability and neurotransmitter release. NTR1 expression in HL-60 cells highlights its importance in hematopoietic cell signaling, while diverse expression across different tissues underscores its potential as a therapeutic target for conditions such as obesity, diabetes, and pain disorders. Anti-NTR1 antibody (G-9) facilitates the study of neurotensin signaling pathways, serving as an invaluable tool for researchers investigating the multifaceted roles of neurotensin in health and disease.

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NTR1 Antibody (G-9) References:

1. Characterization of high affinity neurotensin receptor NTR1 in HL-60 cells and its down regulation during granulocytic differentiation.  |  Choi, SY., et al. 1999. Br J Pharmacol. 126: 1050-6. PMID: 10193787
2. The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin.  |  Pettibone, DJ., et al. 2002. J Pharmacol Exp Ther. 300: 305-13. PMID: 11752130
3. Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors.  |  Hwang, JR., et al. 2010. Biochem Biophys Res Commun. 391: 1007-13. PMID: 19968961
4. Dependence of Relative Expression of NTR1 and EGFR on Cell Density and Extracellular pH in Human Pancreatic Cancer Cell Lines.  |  Olszewski-Hamilton, U. and Hamilton, G. 2011. Cancers (Basel). 3: 182-97. PMID: 24212612
5. Neurotensin receptor 1 facilitates intracellular and transepithelial delivery of macromolecules.  |  Bird, JL., et al. 2017. Eur J Pharm Biopharm. 119: 300-309. PMID: 28690201
6. Isolation and characterization of bacteriophage NTR1 infectious for Nocardia transvalensis and other Nocardia species.  |  Taylor, S., et al. 2019. Virus Genes. 55: 257-265. PMID: 30560472
7. Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity.  |  Fersing, C., et al. 2019. ACS Med Chem Lett. 10: 34-39. PMID: 30655943
8. Neurotensin receptor 1 agonist provides neuroprotection in pre-diabetic rats.  |  Saiyasit, N., et al. 2021. J Endocrinol. 248: 59-74. PMID: 33112810
9. Expression of neurotensin receptor-1 (NTS1) in primary breast tumors, cellular distribution, and association with clinical and biological factors.  |  Morgat, C., et al. 2021. Breast Cancer Res Treat. 190: 403-413. PMID: 34596798
10. Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1.  |  Asadollahi, K., et al. 2023. Nat Commun. 14: 8155. PMID: 38071229

The preferred NTR1 antibody is NTR1 Antibody (B-9): sc-374492.