NTR1 Antibody (B-9): sc-374492

NTR1 Antibody (B-9) is a mouse monoclonal IgM antibody that detects NTR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NTR1 (B-9) antibody is available as non-conjugated anti-NTR1 antibody. NTR1 protein, also known as neurotensin receptor 1, plays a crucial role in mediating physiological effects of neurotensin, a neuropeptide involved in various central and peripheral functions. NTR1 is primarily located in brain and peripheral tissues, contributing to important processes such as regulation of blood pressure, glucose metabolism, thermoregulation, pain modulation, and gastrointestinal motility. Interaction of neurotensin with NTR1 initiates intracellular signaling cascades through G protein coupling, activating multiple pathways, including those involving Gq, Gi/o, and Gs proteins. Activation of NTR1 has been shown to influence expression of pro-inflammatory cytokines in microglial cells, highlighting potential role in neuroinflammatory responses. NTR1′s ability to mediate diverse physiological effects underscores importance in both health and disease, making anti-NTR1 antibody (B-9) a valuable tool for researchers studying neurotensin signaling pathways and implications in various biological contexts.

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NTR1 Antibody (B-9) References:

1. Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.  |  Nielsen, MS., et al. 1999. J Biol Chem. 274: 8832-6. PMID: 10085125
2. Characterization of high affinity neurotensin receptor NTR1 in HL-60 cells and its down regulation during granulocytic differentiation.  |  Choi, SY., et al. 1999. Br J Pharmacol. 126: 1050-6. PMID: 10193787
3. Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line.  |  Navarro, V., et al. 2002. Biochem Biophys Res Commun. 298: 760-4. PMID: 12419319
4. Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia.  |  Martin, S., et al. 2003. J Neurosci. 23: 1198-205. PMID: 12598608
5. Specific involvement of neurotensin type 1 receptor in the neurotensin-mediated in vivo dopamine efflux using knock-out mice.  |  Leonetti, M., et al. 2004. J Neurochem. 89: 1-6. PMID: 15030383
6. Neurotensin depolarizes globus pallidus neurons in rats via neurotensin type-1 receptor.  |  Chen, L., et al. 2004. Neuroscience. 125: 853-9. PMID: 15120846
7. Neurotensin negatively modulates Akt activity in neurotensin receptor-1-transfected AV12 cells.  |  Liu, F., et al. 2004. J Cell Biochem. 92: 603-11. PMID: 15156571
8. Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a murine microglial cell line.  |  Dicou, E., et al. 2004. J Neurosci Res. 78: 92-9. PMID: 15372498
9. Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system.  |  Perron, A., et al. 2005. J Biol Chem. 280: 10219-27. PMID: 15637074
10. Neurotensin and the neurotensin receptor-3 in microglial cells.  |  Martin, S., et al. 2005. J Neurosci Res. 81: 322-6. PMID: 15957186
11. Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosome.  |  Tanaka, N., et al. 2007. Genes Dev. 21: 2312-25. PMID: 17875666
12. The significance of NTR1 expression and its correlation with β-catenin and EGFR in gastric cancer.  |  Zhou, Z., et al. 2015. Diagn Pathol. 10: 128. PMID: 26215716

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NTR1 Antibody (B-9) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-NTR1 Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NTR1 Antibody (B-9) Specifications

Alternate Product Name: NTR1

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 395-423

Epitope Target: NTR1

Epitope Species: rat

Product Reactivity/Detection: NTR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for NTR1 Antibody (B-9): P: Blocking Peptide