NOR-1 Antibody (F-10): sc-393903

NOR-1 Antibody (F-10) is a mouse monoclonal IgG2a antibody that detects NOR-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NOR-1, also known as neuron-derived orphan receptor 1, is a member of the NGFI-B subfamily within the nuclear receptor superfamily, which includes Nur77 and Nurr1. These proteins are classified as orphan nuclear receptors due to the absence of identified ligands, and function as immediate-early genes that respond rapidly to various stimuli, playing crucial roles in cell proliferation, differentiation, and apoptosis. NOR-1 is predominantly expressed in the heart, skeletal muscle, thymus, spleen, and brain, where expression is developmentally regulated, suggesting involvement in neural differentiation. Notably, NOR-1 undergoes chromosomal translocation with the EWS gene, resulting in a fusion protein that influences pre-mRNA splicing, impacting gene expression and cellular function. NOR-1′s ability to interact with specific proteins and regulate critical biological processes underscores its importance in both normal physiology and potential pathophysiological conditions, making anti-NOR-1 antibody (F-10) an essential tool for researchers studying these mechanisms.

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NOR-1 Antibody (F-10) References:

1. NOR-1 modulates the inflammatory response of vascular smooth muscle cells by preventing NFκB activation.  |  Calvayrac, O., et al. 2015. J Mol Cell Cardiol. 80: 34-44. PMID: 25536180
2. The Nuclear Receptor, Nor-1, Induces the Physiological Responses Associated With Exercise.  |  Goode, JM., et al. 2016. Mol Endocrinol. 30: 660-76. PMID: 27144290
3. The nuclear receptor NOR-1 regulates the small muscle protein, X-linked (SMPX) and myotube differentiation.  |  Ferrán, B., et al. 2016. Sci Rep. 6: 25944. PMID: 27181368
4. The nuclear receptor NOR-1/NR4A3 regulates the multifunctional glycoprotein vitronectin in human vascular smooth muscle cells.  |  Martí-Pàmies, I., et al. 2017. FASEB J. 31: 4588-4599. PMID: 28666984
5. The nuclear receptor NOR-1 modulates redox homeostasis in human vascular smooth muscle cells.  |  Alonso, J., et al. 2018. J Mol Cell Cardiol. 122: 23-33. PMID: 30096407
6. NOR-1 distinguishes acinic cell carcinoma from its mimics on fine-needle aspiration biopsy specimens.  |  Nguyen, L., et al. 2020. Hum Pathol. 102: 1-6. PMID: 32416209
7. High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice.  |  Cañes, L., et al. 2021. Hypertension. 77: 557-570. PMID: 33356402
8. Overexpression of Neuron-Derived Orphan Receptor 1 (NOR-1) Rescues Cardiomyocytes from Cell Death and Improves Viability after Doxorubicin Induced Stress.  |  Berg, PC., et al. 2021. Biomedicines. 9: PMID: 34572418
9. NOR-1 (NR4A3) immunostaining on cytologic preparations for the preoperative diagnosis of acinic cell carcinoma of the salivary gland.  |  Krishnan, V., et al. 2022. J Am Soc Cytopathol. 11: 352-358. PMID: 36058827
10. Regulated expression of the nor-1 and ver-1 genes associated with aflatoxin biosynthesis.  |  Skory, CD., et al. 1993. Appl Environ Microbiol. 59: 1642-6. PMID: 8517755

The preferred NOR-1 antibody is NOR-1 Antibody (H-7): sc-393902.