NOR-1 Activators
NOR-1 Activators are a class of chemical compounds that directly or indirectly enhance the functional activity of NOR-1, a protein involved in various cellular processes, such as cell proliferation and differentiation. These activators operate by influencing the specific biochemical pathways that NOR-1 is involved in, leading to its increased activation. For example, Forskolin, a potent activator of adenylyl cyclase, leads to increased levels of cAMP, thereby activating protein kinase A (PKA). PKA then phosphorylates and activates CREB, a transcription factor that binds to the cAMP response element in the NOR-1 gene promoter, culminating in NOR-1 activation. Similarly, Isoproterenol, a non-selective beta-adrenergic agonist, also increases cAMP levels, following the same cascade to activate NOR-1.
On another front, compounds like PMA, Angiotensin II, Bradykinin, Vasopressin, and Thrombin enhance NOR-1 activation by primarily targeting the MAPK/ERK pathway. For instance, PMA activates protein kinase C (PKC), which phosphorylates and activates the MAPK/ERK pathway. The resulting pathway activation leads to the phosphorylation and activation of the transcription factor ELK1, which boosts NOR-1 activation. EGF, LPA, S1P, and Bombesin work through the PI3K/AKT pathway, where they activate CREB to stimulate NOR-1. Through these varied yet specific mechanisms, these chemical compounds can effectively enhance the functional activity of NOR-1, showcasing the intricate and diverse ways chemicals can influence protein function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP). Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and activate CREB. CREB, a transcription factor, binds to the cAMP response element (CRE) in the promoter of the NOR-1 gene, leading to the activation of NOR-1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC can phosphorylate and activate the MAPK/ERK pathway. Activation of the MAPK/ERK pathway leads to the phosphorylation and activation of the transcription factor ELK1, which can enhance the activation of NOR-1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that increases cAMP levels. Increased cAMP activates PKA, which can phosphorylate and activate CREB. CREB then binds to the CRE in the NOR-1 gene promoter, leading to the activation of NOR-1. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA is a potent activator of G protein-coupled receptors, leading to the activation of the PI3K/AKT pathway. AKT can phosphorylate and activate CREB, which binds to the CRE in the NOR-1 gene promoter, leading to the activation of NOR-1. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a potent activator of G protein-coupled receptors, leading to the activation of the PI3K/AKT pathway. AKT can phosphorylate and activate CREB, which binds to the CRE in the NOR-1 gene promoter, leading to the activation of NOR-1. | ||||||
Bombesin | 31362-50-2 | sc-397365 | 1 mg | $79.00 | ||
Bombesin activates G protein-coupled receptors, leading to the activation of the PI3K/AKT pathway. AKT can phosphorylate and activate CREB, which binds to the CRE in the NOR-1 gene promoter, leading to the activation of NOR-1. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $50.00 $75.00 $260.00 $505.00 | 3 | |
Angiotensin II binds to the AT1 receptor, leading to the activation of the PLC/PKC pathway. PKC can phosphorylate and activate the MAPK/ERK pathway. Activation of the MAPK/ERK pathway leads to the phosphorylation and activation of the transcription factor ELK1, which can enhance the activation of NOR-1. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin binds to the B2 receptor, leading to the activation of the PLC/PKC pathway. PKC can phosphorylate and activate the MAPK/ERK pathway. Activation of the MAPK/ERK pathway leads to the phosphorylation and activation of the transcription factor ELK1, which can enhance the activation of NOR-1. | ||||||
Vasopressin | 11000-17-2 | sc-356188 sc-356188A | 5 mg 25 mg | $255.00 $1020.00 | 1 | |
Vasopressin binds to the V1 receptor, leading to the activation of the PLC/PKC pathway. PKC can phosphorylate and activate the MAPK/ERK pathway. Activation of the MAPK/ERK pathway leads to the phosphorylation and activation of the transcription factor ELK1, which can enhance the activation of NOR-1. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $230.00 | ||
Thrombin activates protease-activated receptors, leading to the activation of the PLC/PKC pathway. PKC can phosphorylate and activate the MAPK/ERK pathway. Activation of the MAPK/ERK pathway leads to the phosphorylation and activation of the transcription factor ELK1, which can enhance the activation ofNOR-1. | ||||||