NOR-1 Antibody (H-7): sc-393902

NOR-1 Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects NOR-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NOR-1 Antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NOR-1 (H-7) antibody targets NOR-1 protein, also known as neuron-derived orphan receptor 1, a member of the NGFI-B subfamily within the nuclear receptor superfamily, which includes Nur77 and Nurr1. NOR-1 proteins are classified as orphan nuclear receptors due to the absence of identified ligands, and function as immediate-early genes that respond rapidly to various stimuli, influencing processes such as cell proliferation, differentiation, and apoptosis. NOR-1 is predominantly expressed in tissues such as the heart, skeletal muscle, thymus, spleen, and brain, where expression is developmentally regulated, suggesting involvement in neural differentiation. NOR-1 gene is located on chromosome 9q and undergoes chromosomal translocation with the EWS gene, resulting in a fusion protein that may impact pre-mRNA splicing, further underscoring NOR-1′s significance in cellular processes.

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NOR-1 Antibody (H-7) References:

1. The EWS/NOR1 fusion gene product gains a novel activity affecting pre-mRNA splicing.  |  Ohkura, N., et al. 2002. J Biol Chem. 277: 535-43. PMID: 11673470
2. The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment.  |  Wansa, KD., et al. 2002. J Biol Chem. 277: 33001-11. PMID: 12082103
3. The Nuclear Receptor Nor-1 Is a Pleiotropic Regulator of Exercise-Induced Adaptations.  |  Pearen, MA. and Muscat, GEO. 2018. Exerc Sport Sci Rev. 46: 97-104. PMID: 29346164
4. Nuclear receptor NOR-1 (Neuron-derived Orphan Receptor-1) in pathological vascular remodelling and vascular remodelling.  |  Ballester-Servera, C., et al. 2022. Clin Investig Arterioscler. 34: 229-243. PMID: 35581107
5. Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR-1) Reveals Inverse NOR-1 Agonists.  |  Zaienne, D., et al. 2022. ChemMedChem. 17: e202200259. PMID: 35704774
6. Loss of NOR-1 represses muscle metabolism through mTORC1-mediated signaling and mitochondrial gene expression in C2C12 myotubes.  |  Paez, HG., et al. 2023. FASEB J. 37: e23050. PMID: 37389860
7. Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification.  |  Ballester-Servera, C., et al. 2024. Transl Res. 264: 1-14. PMID: 37690706
8. Antisense oligonucleotide to NOR-1, a novel orphan nuclear receptor, induces migration and neurite extension of cultured forebrain cells.  |  Ohkura, N., et al. 1996. Brain Res Mol Brain Res. 35: 309-13. PMID: 8717368
9. Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family.  |  Ohkura, N., et al. 1996. Biochim Biophys Acta. 1308: 205-14. PMID: 8809112
10. Expression of the putative transcription factor NOR-1 in the nervous, the endocrine and the immune systems and the developing brain of the rat.  |  Maruyama, K., et al. 1997. Neuroendocrinology. 65: 2-8. PMID: 9032769
11. Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA.  |  Ohkura, N., et al. 1998. Gene. 211: 79-85. PMID: 9573341
12. The NGFI-B subfamily of the nuclear receptor superfamily (review).  |  Maruyama, K., et al. 1998. Int J Oncol. 12: 1237-43. PMID: 9592180

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NOR-1 Antibody (H-7) has 25 citations in a variety of scientific publications.

Primary antibodies like Anti-NOR-1 Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NOR-1 Antibody (H-7) Specifications

Alternate Product Name: NOR-1

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 222-259

Epitope Target: NOR-1

Epitope Species: human

Product Reactivity/Detection: NOR-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 25 citations in various scientific publications

Available Conjugates/Forms for NOR-1 Antibody (H-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent