Nectin 2 Antibody (R2.525): sc-32804

Nectin 2 Antibody (R2.525) is a mouse monoclonal IgG1 antibody that detects Nectin 2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Nectin 2 is a crucial member of the nectin family, which plays a significant role in cell adhesion and communication, particularly in viral entry into host cells. Nectin 2 is predominantly expressed in various human tissues, including neuronal cell lines, fibroblasts, keratinocytes, and activated T lymphocytes, highlighting its importance in both neural and immune responses. Nectin 2 exists in two splicing variants, Nectin 2α and Nectin 2δ, which differ in their cytoplasmic and transmembrane regions while sharing identical extracellular domains. Notably, Nectin 2δ undergoes tyrosine phosphorylation upon cell-cell adhesion, a modification essential for interaction with the PDZ domain of afadin, linking Nectin 2δ to the actin cytoskeleton and facilitating cellular signaling pathways. This interaction maintains the structural integrity of cell junctions and mediates the entry of certain herpes simplex virus strains, underscoring Nectin 2′s role in both cell adhesion and viral pathogenesis. Anti-Nectin 2 antibody (R2.525) serves as an invaluable tool for researchers studying these critical processes in human biology and disease.

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Nectin 2 Antibody (R2.525) References:

1. Nectin-2: an intercalated disc protein that maintains cardiac function in a setting of pressure overload.  |  McMullen, JR. 2009. Hypertension. 54: 713-5. PMID: 19667253
2. Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration.  |  Devilard, E., et al. 2013. PLoS One. 8: e77424. PMID: 24116228
3. Nectin-2 (CD112) Is Expressed on Outgrowth Endothelial Cells and Regulates Cell Proliferation and Angiogenic Function.  |  Son, Y., et al. 2016. PLoS One. 11: e0163301. PMID: 27676263
4. Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B.  |  Ogawa, H., et al. 2022. Viruses. 14: PMID: 35062364
5. The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors.  |  Dekanić, A., et al. 2023. Pathol Res Pract. 244: 154416. PMID: 36989846
6. Diagnostic and Prognostic Roles of Urine Nectin-2 and Nectin-4 in Human Bladder Cancer.  |  Miyake, M., et al. 2023. Cancers (Basel). 15: PMID: 37174031
7. Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy.  |  Wienke, J., et al. 2024. Cancer Cell. 42: 283-300.e8. PMID: 38181797
8. Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2.  |  Hu, S., et al. 2024. Structure. 32: 918-929.e4. PMID: 38626767
9. Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling.  |  Agorku, DJ., et al. 2024. Cancer Lett. 595: 216985. PMID: 38821255
10. Tumor-associated neutrophils upregulate Nectin2 expression, creating the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.  |  Luo, H., et al. 2024. J Exp Clin Cancer Res. 43: 258. PMID: 39261943

The preferred Nectin 2 antibody is Nectin 2 Antibody (E-1): sc-271236.