Nectin 2 Activators
Nectin 2, also known as CD112, is a cell adhesion molecule belonging to the nectin family of immunoglobulin-like proteins. It plays a crucial role in various cellular processes, including cell-cell adhesion, migration, and signaling. Nectin 2 is primarily expressed in epithelial and neuronal tissues and is involved in the formation of adherens junctions and the maintenance of tissue integrity. As a cell adhesion molecule, nectin 2 mediates homophilic and heterophilic interactions with other nectin family members and with the herpes simplex virus entry mediator (HVEM), facilitating cell-cell adhesion and communication between adjacent cells. Additionally, nectin 2 has been implicated in the regulation of immune responses and the pathogenesis of certain viral infections.
The activation of nectin 2 involves a complex interplay of molecular events that regulate its adhesive and signaling functions. The binding of nectin 2 to its ligands, including other nectin family members or viral glycoproteins, initiates a cascade of intracellular signaling events that modulate cytoskeletal dynamics and cell behavior. Upon ligand binding, nectin 2 may undergo conformational changes that expose binding sites for cytoskeletal adaptor proteins, leading to the assembly of multiprotein complexes involved in cell adhesion and signaling. Furthermore, post-translational modifications, such as phosphorylation or glycosylation, may regulate the activity and localization of nectin 2, fine-tuning its interactions with other cellular components. Overall, the activation of nectin 2 is essential for its diverse cellular functions and is tightly regulated to maintain tissue homeostasis and integrity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is a derivative of vitamin A and acts as a ligand for nuclear retinoic acid receptors (RARs). Activation of RARs by Retinoic Acid influences gene expression, and it has been suggested to modulate cellular processes related to cell adhesion and migration, potentially impacting Nectin 2 function within these processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a natural compound that activates adenylyl cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP levels can influence various cellular pathways, including those related to cell adhesion and migration. Forskolin-mediated activation of these pathways may indirectly modulate Nectin 2 function as part of cellular adhesion and migration processes. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720, also known as Fingolimod, is a sphingosine-1-phosphate receptor modulator. Its interaction with sphingosine-1-phosphate receptors can affect signaling pathways related to cell adhesion and migration. FTY720-mediated modulation of these pathways may indirectly impact Nectin 2 function as part of cellular adhesion and migration processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a phorbol ester that activates protein kinase C (PKC). PKC is involved in various cellular processes, including signal transduction pathways related to cell adhesion and migration. Activation of PKC by PMA may influence these pathways, potentially modulating Nectin 2 function as part of cellular adhesion and migration processes. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinase (ROCK). Inhibition of ROCK by Y-27632 can impact the actin cytoskeleton and cellular contractility, influencing processes related to cell adhesion and migration. Y-27632-mediated modulation of these processes may indirectly affect Nectin 2 function as part of cellular adhesion and migration. | ||||||
8-CPT-cAMP | 93882-12-3 | sc-201569 sc-201569A | 20 mg 100 mg | $87.00 $316.00 | 19 | |
8-CPT-cAMP is a cell-permeable analog of cyclic AMP (cAMP). Like Forskolin, it influences intracellular cAMP levels and can activate downstream signaling pathways. Elevated cAMP levels may impact cellular processes related to cell adhesion and migration. 8-CPT-cAMP-mediated modulation of these pathways may indirectly affect Nectin 2 function within the context of cellular adhesion and migration processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium levels can activate various signaling pathways involved in cellular processes, including those related to cell adhesion and migration. Ionomycin-mediated modulation of these pathways may indirectly influence Nectin 2 function as part of cellular adhesion and migration processes. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is a small molecule inhibitor of the TGF-β type I receptor, ALK5. Inhibition of ALK5 can lead to altered TGF-β signaling, impacting cellular processes related to cell adhesion and migration. SB431542-mediated modulation of these processes may indirectly affect Nectin 2 function within the context of TGF-β signaling and its cross-talk with other pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that facilitates the transport of calcium ions across cellular membranes. Increased intracellular calcium levels can influence signaling pathways related to cell adhesion and migration. A23187-mediated modulation of these pathways may indirectly impact Nectin 2 function as part of cellular adhesion and migration processes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride is a compound that can modulate the activity of glycogen synthase kinase-3 (GSK-3). GSK-3 is involved in various cellular processes, including those related to cell adhesion and migration. Modulation of GSK-3 by Lithium Chloride may indirectly affect Nectin 2 function within the context of these cellular processes. | ||||||