Date published: 2025-10-17

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Nectin 2 Inhibitors

Nectin 2, a member of the nectin family of cell adhesion molecules, plays a pivotal role in mediating cell-cell adhesion and communication in various tissues. Its function is crucial for the maintenance of tissue integrity and organization, as well as for regulating diverse cellular processes such as migration, proliferation, and signaling. Nectin 2 is primarily expressed in epithelial and neuronal tissues, where it forms adherens junctions and interacts with other nectin family members and herpes simplex virus entry mediator (HVEM) to mediate cell adhesion. Through its adhesive properties, nectin 2 contributes to the formation of stable intercellular contacts and the establishment of tissue architecture. Additionally, nectin 2 is involved in modulating immune responses and has been implicated in the pathogenesis of certain viral infections, highlighting its multifaceted role in cellular physiology. Inhibiting the function of nectin 2 involves targeting its adhesive and signaling properties to disrupt cell-cell interactions and downstream signaling pathways. One approach to inhibition may involve blocking the binding of nectin 2 to its ligands, thereby preventing the formation of adherens junctions and impairing cellular adhesion. This could be achieved through the use of molecules that competitively inhibit the interaction between nectin 2 and its binding partners, either by directly interfering with the binding interface or by inducing conformational changes that hinder ligand recognition. Alternatively, inhibition of nectin 2 function may involve targeting downstream signaling pathways activated upon its engagement with ligands. By interfering with the intracellular signaling cascades initiated by nectin 2 binding, it is possible to disrupt cellular processes mediated by nectin 2, such as cytoskeletal remodeling, migration, and proliferation. Overall, inhibiting nectin 2 function represents a strategy for modulating cell adhesion and communication in various physiological and pathological contexts.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$47.00
$145.00
51
(1)

Dasatinib is a small molecule inhibitor targeting multiple kinases, including Src family kinases. Src family kinases play a role in cellular signaling cascades, and their inhibition by Dasatinib can influence pathways involved in cell adhesion and migration, potentially impacting Nectin 2 function as part of these processes.

Cisplatin

15663-27-1sc-200896
sc-200896A
100 mg
500 mg
$76.00
$216.00
101
(4)

Cisplatin is a platinum-containing chemotherapeutic agent that forms DNA adducts, leading to DNA damage and cell cycle arrest. The cellular responses to DNA damage may indirectly affect Nectin 2 function, as DNA damage response pathways are interconnected with signaling networks regulating cell adhesion and migration.

Ruxolitinib

941678-49-5sc-364729
sc-364729A
sc-364729A-CW
5 mg
25 mg
25 mg
$246.00
$490.00
$536.00
16
(1)

Ruxolitinib is a Janus kinase (JAK) inhibitor that modulates cytokine signaling pathways. The JAK-STAT pathway, targeted by Ruxolitinib, is involved in various cellular processes, and its inhibition may influence pathways related to cell adhesion and migration, potentially impacting Nectin 2 function as part of these processes.

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$56.00
$260.00
$416.00
129
(3)

Sorafenib is a multi-kinase inhibitor targeting Raf kinase and receptor tyrosine kinases. By modulating these kinases, Sorafenib can influence cellular signaling pathways involved in cell adhesion and migration, potentially impacting Nectin 2 function within these processes.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor. The PI3K-Akt pathway, targeted by Wortmannin, is crucial for various cellular functions, including cell adhesion and migration. Inhibition of PI3K may indirectly affect Nectin 2 function as part of these cellular processes regulated by PI3K signaling.

(±)-Blebbistatin

674289-55-5sc-203532B
sc-203532
sc-203532A
sc-203532C
sc-203532D
5 mg
10 mg
25 mg
50 mg
100 mg
$179.00
$307.00
$455.00
$924.00
$1689.00
7
(1)

Blebbistatin is a myosin II inhibitor that affects actin-myosin interactions and inhibits contractile processes in cells. By modulating the cytoskeleton and cellular contractility, Blebbistatin may impact the dynamics of cell adhesion and migration, potentially influencing Nectin 2 function in these processes.

Nilotinib

641571-10-0sc-202245
sc-202245A
10 mg
25 mg
$205.00
$405.00
9
(1)

Nilotinib is a tyrosine kinase inhibitor targeting BCR-ABL and other kinases. Tyrosine kinases are involved in various cellular processes, including signaling pathways related to cell adhesion and migration. Inhibition of these kinases by Nilotinib may indirectly affect Nectin 2 function within the context of cellular adhesion and migration.

PF-562271

717907-75-0sc-478488
sc-478488A
sc-478488B
5 mg
10 mg
50 mg
$306.00
$465.00
$1102.00
3
(1)

PF-562271 is a focal adhesion kinase (FAK) inhibitor. FAK plays a crucial role in integrin-mediated signaling and cellular adhesion. Inhibition of FAK by PF-562271 may impact cellular processes involving adhesion and migration, potentially influencing Nectin 2 function as part of these integrin-mediated signaling pathways.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor. As PI3K is involved in various cellular processes, including cell adhesion and migration, its inhibition by LY294002 may indirectly impact Nectin 2 function within the context of these cellular processes regulated by PI3K signaling.

Tyrphostin B42

133550-30-8sc-3556
5 mg
$26.00
4
(1)

Tyrphostin B42 (AG-490) is a Janus kinase (JAK) inhibitor. The JAK-STAT pathway, targeted by AG-490, is implicated in cellular processes, and its modulation may influence pathways related to cell adhesion and migration, potentially impacting Nectin 2 function within these processes.