Date published: 2025-10-18

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Nectin 2 Inhibitors

Nectin 2, a member of the nectin family of cell adhesion molecules, plays a pivotal role in mediating cell-cell adhesion and communication in various tissues. Its function is crucial for the maintenance of tissue integrity and organization, as well as for regulating diverse cellular processes such as migration, proliferation, and signaling. Nectin 2 is primarily expressed in epithelial and neuronal tissues, where it forms adherens junctions and interacts with other nectin family members and herpes simplex virus entry mediator (HVEM) to mediate cell adhesion. Through its adhesive properties, nectin 2 contributes to the formation of stable intercellular contacts and the establishment of tissue architecture. Additionally, nectin 2 is involved in modulating immune responses and has been implicated in the pathogenesis of certain viral infections, highlighting its multifaceted role in cellular physiology. Inhibiting the function of nectin 2 involves targeting its adhesive and signaling properties to disrupt cell-cell interactions and downstream signaling pathways. One approach to inhibition may involve blocking the binding of nectin 2 to its ligands, thereby preventing the formation of adherens junctions and impairing cellular adhesion. This could be achieved through the use of molecules that competitively inhibit the interaction between nectin 2 and its binding partners, either by directly interfering with the binding interface or by inducing conformational changes that hinder ligand recognition. Alternatively, inhibition of nectin 2 function may involve targeting downstream signaling pathways activated upon its engagement with ligands. By interfering with the intracellular signaling cascades initiated by nectin 2 binding, it is possible to disrupt cellular processes mediated by nectin 2, such as cytoskeletal remodeling, migration, and proliferation. Overall, inhibiting nectin 2 function represents a strategy for modulating cell adhesion and communication in various physiological and pathological contexts.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Mitomycin C

50-07-7sc-3514A
sc-3514
sc-3514B
2 mg
5 mg
10 mg
$65.00
$99.00
$140.00
85
(5)

Mitomycin C is an antineoplastic antibiotic that induces DNA crosslinking and inhibits DNA synthesis. The cellular responses to DNA damage and replication stress triggered by Mitomycin C may indirectly affect Nectin 2 function, given the intricate connections between DNA damage response pathways and signaling networks regulating cell adhesion and migration.