NCAM-L1 Antibody (UJ181.4): sc-53387

NCAM-L1 Antibody (UJ181.4) is a mouse monoclonal IgG1 antibody that detects NCAM-L1 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. NCAM-L1, also known as CD171, is a crucial cell adhesion molecule that plays a significant role in axon guidance and cell migration within the nervous system. NCAM-L1 expression is not only vital for normal neuronal development but also has implications in various human tumors, including neuroblastomas, rhabdomyosarcomas, and Ewing′s sarcomas, where NCAM-L1 may facilitate tumor progression by enhancing cell adhesion and migration. NCAM-L1 presence in these malignancies suggests potential use as a biomarker for tumor aggressiveness and a target for therapeutic intervention. Understanding NCAM-L1 function is essential, as NCAM-L1 contributes to the intricate processes of cell signaling and communication, which are fundamental for both normal physiological functions and pathological conditions. With specificity for human tissues, anti-NCAM-L1 antibody (UJ181.4) is an invaluable tool for researchers investigating the roles of cell adhesion molecules in development and cancer biology.

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NCAM-L1 Antibody (UJ181.4) References:

1. Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities.  |  De Angelis, E., et al. 1999. EMBO J. 18: 4744-53. PMID: 10469653
2. The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins.  |  Thelen, K., et al. 2002. J Neurosci. 22: 4918-31. PMID: 12077189
3. The adhesion molecule L1 (CD171) promotes melanoma progression.  |  Meier, F., et al. 2006. Int J Cancer. 119: 549-55. PMID: 16506207
4. Neural cell adhesion molecule L1-transfected embryonic stem cells promote functional recovery after excitotoxic lesion of the mouse striatum.  |  Bernreuther, C., et al. 2006. J Neurosci. 26: 11532-9. PMID: 17093074
5. Neural cell adhesion molecule L1 modulates type I but not type II inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay.  |  Brand, Y., et al. 2013. J Mol Neurosci. 51: 663-70. PMID: 23760987
6. X-ray structure and function of fibronectin domains two and three of the neural cell adhesion molecule L1.  |  Guédez, G., et al. 2023. FASEB J. 37: e22823. PMID: 36809668
7. Expression of neural cell adhesion molecule L1 during development, in neurological mutants and in the peripheral nervous system.  |  Faissner, A., et al. 1984. Brain Res. 317: 69-82. PMID: 6467033
8. Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3.  |  Montgomery, AM., et al. 1996. J Cell Biol. 132: 475-85. PMID: 8636223
9. Neural cell adhesion molecule L1 in gliomas: correlation with TGF-beta and p53.  |  Tsuzuki, T., et al. 1998. J Clin Pathol. 51: 13-7. PMID: 9577364
10. The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway.  |  Kamiguchi, H., et al. 1998. J Neurosci. 18: 5311-21. PMID: 9651214

The preferred NCAM-L1 antibody is NCAM-L1 Antibody (UJ127.11): sc-53386.