NCAM-L1 Antibody (UJ127.11): sc-53386

NCAM-L1 Antibody (UJ127.11) is a mouse monoclonal IgG1 kappa light chain antibody that detects NCAM-L1 of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-NCAM-L1 antibody (UJ127.11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The neuronal cell adhesion molecule NCAM-L1, also known as CD171, is crucial for axon guidance and cell migration within the nervous system, facilitating proper development and connectivity of neurons. NCAM-L1 expression is not only vital during embryogenesis but also plays a significant role in the pathology of various human tumors, such as neuroblastomas, rhabdomyosarcomas, and Ewing′s sarcomas, where NCAM-L1 may enhance tumor progression by promoting cell adhesion and migration. NCAM-L1 presence in these malignancies underscores NCAM-L1′s potential as a biomarker for cancer diagnosis and a target for therapeutic intervention, making NCAM-L1 (UJ127.11) antibody an essential tool for researchers studying cell adhesion mechanisms and tumor biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

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NCAM-L1 Antibody (UJ127.11) References:

1. Identification of an amino acid sequence motif in the cytoplasmic domain of the NCAM-140 kDa isoform essential for its neuritogenic activity.  |  Kolkova, K., et al. 2000. J Neurochem. 75: 1274-82. PMID: 10936211
2. L1 adhesion molecule (CD 171) in development and progression of human malignant melanoma.  |  Fogel, M., et al. 2003. Cancer Lett. 189: 237-47. PMID: 12490317
3. Adhesion molecules CD171 (L1CAM) and CD24 are expressed by primary neuroendocrine carcinomas of the skin (Merkel cell carcinomas).  |  Deichmann, M., et al. 2003. J Cutan Pathol. 30: 363-8. PMID: 12834484
4. Monoclonal antibodies M340 and UJ181.4 recognize antigens associated with primitive neuroectodermal tumours/tissues.  |  Bourne, S., et al. 1989. Hybridoma. 8: 415-26. PMID: 2550359
5. Expression of neural cell adhesion molecule L1 (CD171) in neuroectodermal and other tumors: An immunohistochemical study of 5155 tumors and critical evaluation of CD171 prognostic value in gastrointestinal stromal tumors.  |  Inaguma, S., et al. 2016. Oncotarget. 7: 55276-55289. PMID: 27419370
6. Artemisinin upregulates neural cell adhesion molecule L1 to attenuate neurological deficits after intracerebral hemorrhage in mice.  |  Wang, J., et al. 2022. Brain Behav. 12: e2558. PMID: 35349764
7. Monoclonal antibody UJ 127:11 detects a 220,000-240,000 kdal. glycoprotein present on a sub-set of neuroectodermally derived cells.  |  Kemshead, JT., et al. 1983. Int J Cancer. 31: 187-95. PMID: 6826247
8. Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling.  |  Jørgensen, OS. 1995. Neurochem Res. 20: 533-47. PMID: 7643959
9. Vase mini-exon usage by NCAM is not restricted to tumours of neuroectodermal origin.  |  Patel, K., et al. 1993. Int J Cancer. 54: 772-7. PMID: 8325706
10. Bone marrow micrometastases in a patient with localized Wilms' tumor.  |  Dominici, C., et al. 1996. Med Pediatr Oncol. 26: 125-8. PMID: 8531850
11. Developmental control of N-CAM expression by Hox and Pax gene products.  |  Edelman, GM. and Jones, FS. 1995. Philos Trans R Soc Lond B Biol Sci. 349: 305-12. PMID: 8577842
12. Neural cell adhesion molecule L1: signaling pathways and growth cone motility.  |  Kamiguchi, H. and Lemmon, V. 1997. J Neurosci Res. 49: 1-8. PMID: 9211984

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NCAM-L1 Antibody (UJ127.11) has 21 citations in a variety of scientific publications.

Primary antibodies like Anti-NCAM-L1 Antibody (UJ127.11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NCAM-L1 Antibody (UJ127.11) Specifications

Alternate Product Name: L1CAM

Product Clone Name: UJ127.11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: NCAM-L1

Epitope Species: human

Product Reactivity/Detection: NCAM-L1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 21 citations in various scientific publications

Available Conjugates/Forms for NCAM-L1 Antibody (UJ127.11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin