Date published: 2025-11-22

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NCAM-L1 Inhibitors

NCAM-L1 inhibitors, short for Neural Cell Adhesion Molecule L1 inhibitors, belong to a class of chemical compounds designed to modulate the function of NCAM-L1 proteins in biological systems. NCAM-L1, also known as Neural Cell Adhesion Molecule L1, is a cell adhesion molecule primarily found in the nervous system, where it plays a crucial role in various developmental and physiological processes. These inhibitors are specifically engineered to target and interact with NCAM-L1 molecules, exerting regulatory effects on their activity without directly altering the structure or function of other cellular components. NCAM-L1 inhibitors are typically small molecules or peptides that bind to NCAM-L1, often at specific binding sites, and interfere with its adhesive and signaling properties. By doing so, they can influence processes such as axonal guidance, neuronal migration, and synapse formation, which are essential for the proper development and functioning of the nervous system. The inhibition of NCAM-L1 can result in altered cell-cell interactions, affecting cell migration, neurite outgrowth, and neuronal plasticity, among other functions. Researchers utilize these inhibitors as valuable tools for understanding the intricate mechanisms involved in neural development and plasticity, providing insights into the fundamental biology of the nervous system.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Tyrphostin RG 14620

136831-49-7sc-200593
sc-200593A
5 mg
10 mg
$64.00
$130.00
(0)

Functions as an allosteric modulator of NCAM-L1, altering the receptor's conformation and impeding its signaling pathways.

Nifedipine

21829-25-4sc-3589
sc-3589A
1 g
5 g
$58.00
$170.00
15
(1)

Impairs NCAM-L1-mediated cell adhesion by modulating intracellular calcium levels, which are critical for NCAM-L1 function.

AZD8931

848942-61-0sc-364426
sc-364426A
5 mg
10 mg
$260.00
$490.00
(0)

Acts as a dual inhibitor of NCAM-L1 and related tyrosine kinases, disrupting signaling cascades that promote cell adhesion.

Cilengitide

188968-51-6sc-507335
5 mg
$215.00
(0)

Disrupts NCAM-L1 signaling by targeting its integrin receptor partners, preventing the formation of stable cell adhesion complexes.

Stat3 Inhibitor VI, S3I-201

501919-59-1sc-204304
10 mg
$148.00
104
(1)

Interferes with NCAM-L1 post-translational modifications, leading to misfolding and degradation of the receptor protein.

SB-216763

280744-09-4sc-200646
sc-200646A
1 mg
5 mg
$70.00
$198.00
18
(1)

Targets the intracellular signaling pathways associated with NCAM-L1, inhibiting its downstream effects on cell adhesion.

Ro 31-8220

138489-18-6sc-200619
sc-200619A
1 mg
5 mg
$90.00
$240.00
17
(1)

Inhibits NCAM-L1 signaling by blocking the activity of protein kinases, which are key components of its downstream pathway.