Molecular structure of Tyrphostin RG 14620, CAS Number: 136831-49-7
Tyrphostin RG 14620 (CAS 136831-49-7)
Application:
Tyrphostin RG 14620 is a non-phenolic tyrphostin analog selective for the EGF receptor
CAS Number:
136831-49-7
Purity:
≥98%
Molecular Weight:
275.14
Molecular Formula:
C14H8Cl2N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Tyrphostin RG 14620 is a non-phenolic tyrphostin analog, which is selective for the EGFR (EGF receptor). The compound inhibits EGF-stimulated HER14 cell proliferation (IC50=3 μM) as well as tumor growth in vivo. Tyrphostin RG 14620 contains anti-proliferative effects on renal and bladder carcinoma cell lines. Tyrphostin RG 14620 is an inhibitor of Tyrosine Kinase.
Tyrphostin RG 14620 (CAS 136831-49-7) References
- Tyrphostins and retinoids cooperate during inhibition of in vitro growth of ovarian cancer cells. | Grunt, TW. 2003. Cancer Lett. 189: 147-56. PMID: 12490307
- The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. | Yoneda, T., et al. 1991. Cancer Res. 51: 4430-5. PMID: 1651159
- Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways. | Grunt, TW., et al. 2007. J Cell Physiol. 211: 803-15. PMID: 17286282
- [Effect of signal transduction inhibitors on human endometrial carcinoma cells with differential PTEN gene expression]. | Xiao, L., et al. 2009. Zhonghua Fu Chan Ke Za Zhi. 44: 681-5. PMID: 20079181
- EGFR- and AKT-mediated reduction in PTEN expression contributes to tyrphostin resistance and is reversed by mTOR inhibition in endometrial cancer cells. | Li, T., et al. 2012. Mol Cell Biochem. 361: 19-29. PMID: 21952748
- Tyrphostin RG14620 selectively reverses ABCG2-mediated multidrug resistance in cancer cell lines. | Wu, CP., et al. 2017. Cancer Lett. 409: 56-65. PMID: 28893612
- Dispositional characteristics of a tyrosine kinase inhibitor (RG 14620) in rats and rabbits following intravenous administration or dermal application. | Khetarpal, VK., et al. 1994. Drug Metab Dispos. 22: 216-23. PMID: 8013277
- Antiproliferative effect of tyrosine kinase inhibitors in epidermal growth factor-stimulated growth of human gastric cancer cells. | Piontek, M., et al. 1993. Anticancer Res. 13: 2119-23. PMID: 8297123
- Antiproliferative effects of tyrosine kinase inhibitors (tyrphostins) on human bladder and renal carcinoma cells. | Sion-Vardy, N., et al. 1995. J Surg Res. 59: 675-80. PMID: 8538164
- Photoinstability of some tyrphostin drugs: chemical consequences of crystallinity. | Kumar, N., et al. 1995. Pharm Res. 12: 1708-15. PMID: 8592674
Inhibitor of:
EGFR, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrphostin RG 14620, 5 mg | sc-200593 | 5 mg | $64.00 | |||
Tyrphostin RG 14620, 10 mg | sc-200593A | 10 mg | $130.00 |