NCAM-L1 Antibody (74-5H7): sc-59868

NCAM-L1 Antibody (74-5H7) is a mouse monoclonal IgG1 antibody that detects NCAM-L1 in mouse, rat, human, equine, and avian species through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). NCAM-L1, also known as CD171, is a crucial cell adhesion molecule that plays a significant role in axon guidance and cell migration within the nervous system. NCAM-L1 expression is particularly important during embryonic development and in various human tumors, including neuroblastomas and rhabdomyosarcomas, where NCAM-L1 may facilitate tumor progression by enhancing cell adhesion and migration. The structure of NCAM-L1 is characterized by immunoglobulin-like domains, which are essential for mediating interactions between cells. These interactions are vital for maintaining the integrity of neural networks and ensuring proper neuronal function. NCAM-L1′s ability to engage in homophilic binding allows for the stabilization of cell-cell contacts, which is critical for the development of the nervous system and the response to injury. Using anti-NCAM-L1 antibody (74-5H7) in research can provide valuable insights into the mechanisms of cell adhesion and migration, as well as their implications in tumor biology and neurodevelopmental processes.

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NCAM-L1 Antibody (74-5H7) References:

1. Immunolocalization of the neural cell adhesion molecule L1 in epithelia of rodents.  |  Nolte, C., et al. 1999. Cell Tissue Res. 298: 261-73. PMID: 10571115
2. The human neural cell adhesion molecule L1 functions as a costimulatory molecule in T cell activation.  |  Balaian, LB., et al. 2000. Eur J Immunol. 30: 938-43. PMID: 10741412
3. Differential expression of alternatively spliced neural cell adhesion molecule L1 isoforms during oligodendrocyte maturation.  |  Itoh, K., et al. 2000. J Neurosci Res. 60: 579-86. PMID: 10820428
4. Expression and function of the neural cell adhesion molecule L1 in mouse leukocytes.  |  Kowitz, A., et al. 1992. Eur J Immunol. 22: 1199-205. PMID: 1577062
5. Cryo-electron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1.  |  He, Y., et al. 2009. Structure. 17: 460-71. PMID: 19278660
6. Effects of ethanol and NAP on cerebellar expression of the neural cell adhesion molecule L1.  |  Fitzgerald, DM., et al. 2011. PLoS One. 6: e24364. PMID: 21931691
7. The Neuroprotective Effect of Neural Cell Adhesion Molecule L1 in the Hippocampus of Aged Alzheimer's Disease Model Mice.  |  Aksic, M., et al. 2024. Biomedicines. 12: PMID: 39200191
8. Regulated expression of the neural cell adhesion molecule L1 by specific patterns of neural impulses.  |  Itoh, K., et al. 1995. Science. 270: 1369-72. PMID: 7481827
9. Immunolocalization of the neural cell adhesion molecule L1 in non-proliferating epithelial cells of the male urogenital tract.  |  Kujat, R., et al. 1995. Histochem Cell Biol. 103: 311-21. PMID: 7648407
10. Several extracellular domains of the neural cell adhesion molecule L1 are involved in homophilic interactions.  |  Holm, J., et al. 1995. J Neurosci Res. 42: 9-20. PMID: 8531230

The preferred NCAM-L1 antibody is NCAM-L1 Antibody (UJ127.11): sc-53386.