MYL7 Antibody (D-9): sc-515026

MYL7 Antibody (D-9) is a mouse monoclonal IgG1 antibody that detects myosin regulatory light chain 7 (MYL7) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MYL7 antibody (D-9) targets a crucial component of cardiac muscle, encoded by the MYL7 gene, which plays a significant role in muscle contraction and relaxation by regulating the interaction between actin and myosin filaments. MYL7 (D-9) antibody recognizes a protein predominantly expressed in adult atrial muscle, where MYL7 forms part of a hexameric complex consisting of two heavy chains and four light chains. MYL7′s ability to bind calcium is vital for cardiac function, as MYL7 influences the contractile properties of the heart. The co-expression of MYL7 with myosin light chain 2 in specific regions of the heart allows for precise delineation of cardiac chamber boundaries, which is essential for understanding cardiac development and function. A remarkable 95% homology exists at the amino acid level between human and mouse MYL7 sequences, making MYL7 (D-9) monoclonal antibody a valuable tool for comparative studies in cardiac research.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MYL7 Antibody (D-9) References:

1. The role of endothelial cilia in postembryonic vascular development.  |  Elworthy, S., et al. 2019. Dev Dyn. 248: 410-425. PMID: 30980582
2. Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice.  |  Sun, J., et al. 2022. J Cell Mol Med. 26: 88-98. PMID: 34854218
3. Generation of a dual edited human induced pluripotent stem cell Myl7-GFP reporter line with inducible CRISPRi/dCas9.  |  Metzl-Raz, E., et al. 2022. Stem Cell Res. 61: 102754. PMID: 35325819
4. Fabrication of human myocardium using multidimensional modelling of engineered tissues.  |  Montero-Calle, P., et al. 2022. Biofabrication. 14: PMID: 36007502
5. Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism.  |  Lou, B., et al. 2023. J Transl Med. 21: 199. PMID: 36927819
6. Generation of cardiomyocytes from human-induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists.  |  Ahmad, FS., et al. 2023. Philos Trans R Soc Lond B Biol Sci. 378: 20220312. PMID: 37122218
7. Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels.  |  Ji, Y., et al. 2023. Arterioscler Thromb Vasc Biol. 43: e254-e269. PMID: 37128921
8. Biophysical properties of NaV1.5 channels from atrial-like and ventricular-like cardiomyocytes derived from human induced pluripotent stem cells.  |  Chapotte-Baldacci, CA., et al. 2023. Sci Rep. 13: 20685. PMID: 38001331
9. Genome-wide analysis in PC6 electroacupuncture to ameliorate carfilzomib-induced cardiotoxicity in mice.  |  Chen, Y., et al. 2024. Gene. 897: 148090. PMID: 38110043
10. Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.  |  Michael, BD., et al. 2023. Nat Commun. 14: 8487. PMID: 38135686

The preferred MYL7 antibody is MYL7 Antibody (B-10): sc-365255.