MYL7 Inhibitors
The provided table includes chemicals that influence the function of MYL7 through the modulation of myosin ATPase activity, kinase activity that regulates myosin light chain phosphorylation, or calcium signaling related to muscle contraction. These indirect mechanisms could alter the phosphorylation state of MYL7, which in turn modulates the interaction of MYL7 with myosin and affects muscle contractility.
In a discussion about inhibitors that could indirectly affect MYL7, we would consider compounds that interfere with the regulatory mechanisms controlling muscle contraction. The regulatory processes include the phosphorylation of myosin light chains by kinases such as MLCK and the impact of calcium signaling, which is a key factor in muscle contraction. By altering kinase activity or calcium signaling, these compounds can modify the interaction between MYL7 and the myosin heavy chain, thereby influencing muscle contractile dynamics. The specific effects of such compounds on MYL7 would vary based on multiple factors, including their concentration, specificity for their primary targets, and the cellular context within the cardiac muscle cells.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
An inhibitor of myosin II ATPase activity that can prevent myosin from performing the power stroke, potentially affecting the function of associated myosin light chains like MYL7. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
An inhibitor of myosin light chain kinase (MLCK), which phosphorylates myosin light chains, possibly reducing the phosphorylation and activity of MYL7. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
A calmodulin antagonist affecting calcium signaling, which could indirectly reduce MLCK-mediated phosphorylation of MYL7. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor which may decrease the phosphorylation state of myosin light chains by inhibiting Rho-associated kinase that can influence MLCK. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
A protein kinase C inhibitor that might alter the phosphorylation state of proteins involved in muscle contraction, potentially affecting MYL7 indirectly. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
An inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII), which could modulate the phosphorylation of proteins in cardiac muscle, including MYL7. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent inhibitor of protein kinases that may non-specifically reduce the phosphorylation of myosin light chains like MYL7. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
An inhibitor of protein kinase A (PKA), which could influence the phosphorylation and function of proteins in cardiac muscle cells, including MYL7. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
A phosphatase inhibitor that prevents dephosphorylation of many proteins, which could indirectly keep MYL7 in a phosphorylated state. | ||||||
2,3-Butanedione 2-Monoxime | 57-71-6 | sc-203774 sc-203774A sc-203774B sc-203774C | 25 g 100 g 250 g 500 g | $41.00 $76.00 $158.00 $280.00 | ||
2,3-Butanedione monoxime, an agent known to inhibit myosin ATPase, potentially affecting myosin light chain function. | ||||||