muscle FBPase Antibody (E-11): sc-390209
- muscle FBPase Antibody (E-11) is a mouse monoclonal IgG2b κ muscle FBPase antibody, cited in 1 publications, provided at 200 µg/ml
- raised against a peptide mapping at the C-terminus of muscle FBPase of human origin
- muscle FBPase Antibody (E-11) is recommended for detection of muscle FBPase of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- Anti-muscle FBPase Antibody (E-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for muscle FBPase Antibody (E-11) for WB applications. These reagents are now offered in bundles with muscle FBPase Antibody (E-11) (see ordering information below).
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muscle FBPase Antibody (E-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects muscle FBPase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). muscle FBPase (E-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Fructose-1,6-bisphosphatase (FBPase) plays a crucial role in carbohydrate metabolism by catalyzing the conversion of fructose-1,6-bisphosphate into fructose 6-phosphate and inorganic phosphate, a key step in gluconeogenesis. This enzymatic activity helps maintain glucose homeostasis, especially during fasting or intense exercise, by regulating blood sugar levels. The muscle isoform of FBPase, encoded by the FBP2 gene, supports energy production in muscle tissues during periods of low glucose availability. AMP regulates FBPase activity through inhibition, influencing dependent metabolic pathways. Mutations in the FBP1 gene, which encodes the liver isoform, can lead to serious metabolic disorders, highlighting FBPase′s importance in overall metabolic health. The muscle FBPase protein′s strategic location on both sides of the Z-line in muscle fibers facilitates energy metabolism during muscle contraction and relaxation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
muscle FBPase Antibody (E-11) References:
- Two newly identified genomic mutations in a Japanese female patient with fructose-1,6-bisphosphatase (FBPase) deficiency. | Matsuura, T., et al. 2002. Mol Genet Metab. 76: 207-10. PMID: 12126934
- Different sensitivities of mutants and chimeric forms of human muscle and liver fructose-1,6-bisphosphatases towards AMP. | Rakus, D., et al. 2003. Biol Chem. 384: 51-8. PMID: 12674499
- Interaction between muscle aldolase and muscle fructose 1,6-bisphosphatase results in the substrate channeling. | Rakus, D., et al. 2004. Biochemistry. 43: 14948-57. PMID: 15554702
- Nuclear localization of fructose 1,6-bisphosphatase in smooth muscle cells. | Gizak, A., et al. 2005. J Mol Histol. 36: 243-8. PMID: 16200456
- Purification of human liver fructose-1,6-bisphosphatase. | Dzugaj, A. and Kochman, M. 1980. Biochim Biophys Acta. 614: 407-12. PMID: 6250626
- Function, structure and evolution of fructose-1,6-bisphosphatase. | Marcus, F., et al. 1987. Arch Biol Med Exp. 20: 371-8. PMID: 8816077
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
muscle FBPase Antibody (E-11) | sc-390209 | 200 µg/ml | $322.00 | |||
muscle FBPase Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-523450 | 200 µg Ab, 40 µg BP | $361.00 | |||
muscle FBPase Antibody (E-11): m-IgG2b BP-HRP Bundle | sc-549119 | 200 µg Ab; 10 µg BP | $361.00 | |||
muscle FBPase Antibody (E-11) AC | sc-390209 AC | 500 µg/ml, 25% agarose | $424.00 | |||
muscle FBPase Antibody (E-11) HRP | sc-390209 HRP | 200 µg/ml | $322.00 | |||
muscle FBPase Antibody (E-11) FITC | sc-390209 FITC | 200 µg/ml | $336.00 | |||
muscle FBPase Antibody (E-11) PE | sc-390209 PE | 200 µg/ml | $349.00 | |||
muscle FBPase Antibody (E-11) Alexa Fluor® 488 | sc-390209 AF488 | 200 µg/ml | $364.00 | |||
muscle FBPase Antibody (E-11) Alexa Fluor® 546 | sc-390209 AF546 | 200 µg/ml | $364.00 | |||
muscle FBPase Antibody (E-11) Alexa Fluor® 594 | sc-390209 AF594 | 200 µg/ml | $364.00 | |||
muscle FBPase Antibody (E-11) Alexa Fluor® 647 | sc-390209 AF647 | 200 µg/ml | $364.00 | |||
muscle FBPase Antibody (E-11) Alexa Fluor® 680 | sc-390209 AF680 | 200 µg/ml | $364.00 | |||
muscle FBPase Antibody (E-11) Alexa Fluor® 790 | sc-390209 AF790 | 200 µg/ml | $364.00 | |||
muscle FBPase (E-11) Neutralizing Peptide | sc-390209 P | 100 µg/0.5 ml | $69.00 |