muscle FBPase Activators
Muscle FBPase activators are chemicals that enhance the activity of the enzyme fructose-1,6-bisphosphatase (FBPase) found in muscle tissue, which is a crucial component in the gluconeogenic pathway. This metabolic route enables the synthesis of glucose from non-carbohydrate precursors, a physiological process essential for maintaining blood glucose levels during periods of fasting or intense exercise. The role of muscle FBPase is to catalyze the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate, a key step in producing glucose within the muscle cell.
Activators of muscle FBPase can operate through a variety of mechanisms. Direct activators may bind to the enzyme and induce conformational changes that increase its affinity for substrates or enhance its catalytic efficiency. These can interact with the active site or with allosteric sites-regions of the enzyme distinct from the active site that can modulate the enzyme's activity when occupied by an effector molecule. On the other hand, indirect activators may influence the enzyme's activity by altering intracellular signaling pathways that regulate its expression or by affecting the enzyme's post-translational modifications, which can impact its stability and activity. Research into muscle FBPase activators is driven by an interest in the fundamental mechanisms controlling glucose production within muscle cells and the broader metabolic implications of these processes. By studying these activators, researchers aim to gain a deeper understanding of the regulation of gluconeogenesis and its integration within the complex network of metabolic pathways. The exploration of muscle FBPase activators is also valuable for elucidating the cellular response to energy demands and the maintenance of glucose homeostasis under various physiological conditions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Fructose 1,6-bisphosphate sodium salt | 488-69-7 | sc-484714 | 50 g | $304.00 | ||
Fructose 1,6-bisphosphate, the immediate product of FBPase, can indirectly enhance its activity. By allosterically activating phosphofructokinase 1 (PFK1), it increases the rate of the glycolytic flux, which can lead to the consumption of more fructose 6-phosphate, the substrate of FBPase, thereby driving its activity. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $50.00 $110.00 $145.00 $248.00 $598.00 | 1 | |
Citrate is a known allosteric activator of FBPase. It binds to an allosteric site on FBPase, changing its conformation and enhancing its enzymatic activity. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Alpha-ketoglutarate can indirectly enhance FBPase activity. By increasing TCA cycle flux, it can increase the production of citrate, which is a direct activator of FBPase. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $45.00 $75.00 $133.00 | ||
Succinate can indirectly enhance FBPase activity. By promoting the TCA cycle, it can increase the production of citrate, which is a direct activator of FBPase. | ||||||
Malic acid | 6915-15-7 | sc-257687 | 100 g | $130.00 | 2 | |
L-malic acid can indirectly enhance FBPase activity. By promoting the TCA cycle, it can increase the production of citrate, a direct activator of FBPase. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ can indirectly enhance FBPase activity. By promoting the oxidation reactions in the TCA cycle, it can increase the production of citrate, which is a direct activator of FBPase. | ||||||
Coenzyme A | 85-61-0 anhydrous | sc-211123 sc-211123A sc-211123B sc-211123C | 10 mg 25 mg 100 mg 250 mg | $83.00 $135.00 $418.00 $801.00 | 1 | |
Coenzyme A can indirectly enhance FBPase activity. By promoting the TCA cycle, it can increase the production of citrate, which is a direct activator of FBPase. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP can indirectly enhance FBPase activity. By providing the energy needed for the TCA cycle, it can increase the production of citrate, which is a direct activator of FBPase. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
Glutamate can indirectly enhance FBPase activity. By promoting the conversion of alpha-ketoglutarate to succinate in the TCA cycle, it can increase the production of citrate, which is a direct activator of FBPase. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $41.00 $96.00 | ||
Pyruvate can indirectly enhance FBPase activity. By promoting the conversion of pyruvate to acetyl-CoA, it can increase the production of citrate, which is a direct activator of FBPase. | ||||||