mGluR-2 Antibody (A-7): sc-271655

mGluR-2 Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects mGluR-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). mGluR-2 (A-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. mGluR-2, a member of the metabotropic glutamate receptor family, plays a crucial role in modulating synaptic transmission and plasticity in the central nervous system. mGluR-2 is primarily located in presynaptic terminals of neurons, where mGluR-2 regulates neurotransmitter release, thereby influencing neuronal excitability and communication. This localization is vital for maintaining the balance of excitatory and inhibitory signals in the brain, which is essential for normal cognitive functions and emotional regulation. Dysregulation of mGluR-2 has been implicated in various neurological disorders, including schizophrenia and anxiety, making mGluR-2 a significant target for therapeutic interventions. mGluR-2′s interaction with proteins such as GRASP further highlights mGluR-2′s importance in synaptic stability and neurotransmission regulation, underscoring anti-mGluR-2 antibody (A-7)′s relevance in research focused on neurobiology and related fields.

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mGluR-2 Antibody (A-7) References:

1. Activation of metabotropic glutamate receptor 1 dimers requires glutamate binding in both subunits.  |  Kammermeier, PJ. and Yun, J. 2005. J Pharmacol Exp Ther. 312: 502-8. PMID: 15466247
2. Immunocytochemical localization of metabotropic (mGluR2/3 and mGluR4a) and ionotropic (GluR2/3) glutamate receptors in adrenal medullary ganglion cells.  |  Sarría, R., et al. 2006. Histol Histopathol. 21: 141-7. PMID: 16329038
3. The mGlu2/3 receptor agonist LY354740 suppresses immobilization stress-induced increase in rat prefrontal cortical BDNF mRNA expression.  |  Lee, Y., et al. 2006. Neurosci Lett. 398: 328-32. PMID: 16469447
4. mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses.  |  Nicholls, RE., et al. 2006. Proc Natl Acad Sci U S A. 103: 6380-5. PMID: 16606834
5. An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats.  |  Yoshimizu, T., et al. 2006. Psychopharmacology (Berl). 186: 587-93. PMID: 16612616
6. Metabotropic glutamate receptors as a strategic target for the treatment of epilepsy.  |  Alexander, GM. and Godwin, DW. 2006. Epilepsy Res. 71: 1-22. PMID: 16787741
7. Abnormal mGluR2/3 expression in the perforant path termination zones and mossy fibers of chronically epileptic rats.  |  Pacheco Otalora, LF., et al. 2006. Brain Res. 1098: 170-85. PMID: 16793029
8. The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function.  |  Moha ou Maati, H., et al. 2016. Brain Struct Funct. 221: 21-37. PMID: 25233810
9. Effects of Clavulanic Acid Treatment on Reinstatement to Methamphetamine, Glial Glutamate Transporters, and mGluR 2/3 Expression in P Rats Exposed to Ethanol.  |  Althobaiti, YS., et al. 2019. J Mol Neurosci. 67: 1-15. PMID: 30471010
10. Discovery of 6,7-Dihydropyrazolo[1,5-a]pyrazin-4(5H)-one Derivatives as mGluR2 Negative Allosteric Modulators with In Vivo Activity in a Rodent's Model of Cognition.  |  Alonso de Diego, SA., et al. 2024. J Med Chem. 67: 15569-15585. PMID: 39208150
11. The anti-dyskinetic effect of the clinic-ready mGluR2 positive allosteric modulator AZD8529 in the 6-OHDA-lesioned rat.  |  Shaqfah, J., et al. 2025. Naunyn Schmiedebergs Arch Pharmacol.. PMID: 39841218
12. Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2.  |  Flor, PJ., et al. 1995. Eur J Neurosci. 7: 622-9. PMID: 7620613

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-mGluR-2 Antibody (A-7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-mGluR-2 Antibody (A-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

mGluR-2 Antibody (A-7) Specifications

Alternate Product Name: mGluR-2

Product Clone Name: A-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 407-536

Epitope Target: mGluR-2

Epitope Species: human

Product Reactivity/Detection: mGluR-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for mGluR-2 Antibody (A-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred mGluR-2 antibody is mGluR-2 Antibody (A-1): sc-271654.