mGluR-2 Inhibitors
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Items 1 to 10 of 19 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 341495 | 201943-63-7 | sc-361244 sc-361244A | 1 mg 10 mg | $87.00 $219.00 | 1 | |
LY 341495 is a selective antagonist of mGluR-2, characterized by its ability to disrupt the receptor's conformational state through specific hydrophobic interactions. This compound exhibits rapid binding kinetics, leading to immediate inhibition of receptor activity. Its unique structural features enable it to selectively influence intracellular signaling cascades, modulating calcium ion flux and impacting neurotransmitter release dynamics, thereby affecting synaptic communication. | ||||||
(RS)-CPPG | 183364-82-1 | sc-203448 sc-203448A | 5 mg 25 mg | $408.00 $1224.00 | 1 | |
(RS)-CPPG acts as a potent mGluR-2 agonist, engaging the receptor through distinct electrostatic interactions that stabilize its active conformation. This compound demonstrates a unique ability to enhance receptor-mediated signaling pathways, promoting downstream effects on neuronal excitability. Its selective binding affinity allows for precise modulation of synaptic plasticity, influencing glutamate release and receptor desensitization, thereby shaping neural network dynamics. | ||||||
E4CPG | 170846-89-6 | sc-205943 sc-205943A | 10 mg 50 mg | $129.00 $548.00 | ||
E4CPG functions as a selective mGluR-2 agonist, characterized by its unique ability to form hydrogen bonds with key amino acid residues in the receptor's binding pocket. This interaction facilitates a conformational shift that enhances receptor activation. E4CPG exhibits distinct kinetic properties, allowing for rapid onset and prolonged engagement with the receptor, which influences intracellular calcium signaling and modulates synaptic transmission efficiency. Its specificity contributes to nuanced regulatory effects on neuronal circuits. | ||||||
(RS)-MCPG disodium salt | 1303994-09-3 | sc-358840 | 10 mg | $160.00 | ||
(RS)-MCPG disodium salt acts as a selective mGluR-2 antagonist, distinguished by its capacity to disrupt the receptor's signaling pathways. It engages in specific electrostatic interactions with charged residues, leading to a stabilization of the inactive receptor conformation. This compound exhibits unique binding kinetics, characterized by a slow dissociation rate, which prolongs its inhibitory effects on downstream signaling cascades, ultimately influencing neurotransmitter release dynamics. | ||||||
MPEP hydrochloride | 96206-92-7 | sc-279454A sc-279454 | 10 mg 50 mg | $133.00 $510.00 | ||
Primarily an mGluR5 antagonist, but it can also influence other pathways that may affect mGluR-2 function indirectly. | ||||||
(RS)-MCPG | 146669-29-6 | sc-202325 | 5 mg | $134.00 | ||
(RS)-MCPG functions as a selective antagonist for mGluR-2, exhibiting unique molecular interactions that modulate receptor activity. Its binding affinity is influenced by hydrophobic contacts and hydrogen bonding with key amino acid residues, which alters receptor conformational states. The compound's distinct reaction kinetics reveal a prolonged engagement with the receptor, effectively modulating intracellular calcium levels and impacting synaptic plasticity through altered signaling pathways. | ||||||
(S)-MCPG | 150145-89-4 | sc-202329 sc-202329A | 5 mg 25 mg | $143.00 $945.00 | ||
(S)-MCPG acts as a selective antagonist for mGluR-2, showcasing unique binding dynamics that influence receptor conformation. Its interactions involve specific electrostatic and hydrophobic forces, leading to a distinct modulation of downstream signaling cascades. The compound's kinetic profile indicates a slow dissociation rate from the receptor, which may enhance its regulatory effects on neurotransmitter release and synaptic transmission, contributing to nuanced cellular responses. | ||||||
Ro 64-5229 | 246852-46-0 | sc-361308 sc-361308A | 10 mg 50 mg | $350.00 $1575.00 | ||
Ro 64-5229 is a selective mGluR-2 modulator that exhibits unique allosteric properties, enhancing receptor activity through specific conformational changes. Its binding involves intricate hydrogen bonding and hydrophobic interactions, which stabilize the receptor in an active state. The compound demonstrates a rapid onset of action, influencing intracellular calcium signaling and gene expression pathways, thereby affecting neuronal excitability and synaptic plasticity in a distinctive manner. | ||||||
L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) | 23052-81-5 | sc-200432 | 5 mg | $92.00 | 1 | |
It is an agonist for group III mGluRs, but its activity can indirectly influence mGluR-2. | ||||||
LY 341495 disodium salt | sc-362765 sc-362765A | 1 mg 10 mg | $112.00 $177.00 | |||
LY 341495 disodium salt acts as a selective modulator of mGluR-2, exhibiting unique binding dynamics that promote receptor desensitization. Its interaction profile includes specific electrostatic and van der Waals forces, which facilitate a nuanced alteration in receptor conformation. This compound influences downstream signaling cascades, particularly those involving phosphoinositide turnover, thereby modulating synaptic transmission and neuronal network activity with distinct kinetics. | ||||||