mGluR-2 Antibody (A-1): sc-271654

mGluR-2 Antibody (A-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects mGluR-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-mGluR-2 antibody (A-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. mGluR-2, a member of the metabotropic glutamate receptor family, plays a crucial role in modulating synaptic transmission and plasticity in the central nervous system. mGluR-2 is primarily located in the postsynaptic membranes of neurons, where mGluR-2 is involved in the regulation of neurotransmitter release and synaptic signaling. This localization is vital for maintaining proper neuronal communication and plasticity, which are essential for learning and memory processes. Additionally, mGluR-2 has been implicated in various neurological disorders, making mGluR-2 a significant target for therapeutic interventions. mGluR-2′s interaction with other proteins, such as GRASP, further highlights mGluR-2′s importance in synaptic stabilization and the overall regulation of glutamatergic signaling pathways.

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mGluR-2 Antibody (A-1) References:

1. Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependence.  |  Kufahl, PR., et al. 2011. Neuropsychopharmacology. 36: 2762-73. PMID: 21881571
2. The mGluR2/3 agonist LY379268 reverses NMDA receptor antagonist effects on cortical gamma oscillations and phase coherence, but not working memory impairments, in mice.  |  Sokolenko, E., et al. 2019. J Psychopharmacol. 33: 1588-1599. PMID: 31580222
3. Environmental enrichment and a selective metabotropic glutamate receptor2/3 (mGluR2/3) agonist suppress amphetamine self-administration: Characterizing baseline differences.  |  Garcia, EJ. and Cain, ME. 2020. Pharmacol Biochem Behav. 192: 172907. PMID: 32179027
4. Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.  |  Liu, J., et al. 2021. Neural Regen Res. 16: 727-733. PMID: 33063735
5. Additive effects of mGluR2 positive allosteric modulation, mGluR2 orthosteric stimulation and 5-HT2AR antagonism on dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.  |  Nuara, SG., et al. 2021. Naunyn Schmiedebergs Arch Pharmacol. 394: 2381-2388. PMID: 34550406
6. Anxiolytic-like effects of an mGluR 5 antagonist and a mGluR 2/3 agonist, and antidepressant-like effects of an mGluR 7 agonist in the chick social separation stress test, a dual-drug screening model of treatment-resistant depression.  |  White, SW., et al. 2023. Pharmacol Biochem Behav. 227-228: 173588. PMID: 37348610
7. The mGluR2/3 orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.  |  Kang, W., et al. 2023. Naunyn Schmiedebergs Arch Pharmacol. 396: 2347-2355. PMID: 37410156
8. Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators.  |  Perkins, JJ., et al. 2023. ACS Med Chem Lett. 14: 986-992. PMID: 37465306
9. Positive allosteric mGluR2 modulation with BINA alleviates dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.  |  Kang, W., et al. 2024. Naunyn Schmiedebergs Arch Pharmacol. 397: 8917-8924. PMID: 38861009
10. Effect of mGluR2 and mGluR2/3 activators on parkinsonism in the MPTP-lesioned non-human primate.  |  Frouni, I., et al. 2024. Naunyn Schmiedebergs Arch Pharmacol. 397: 9135-9147. PMID: 38900249

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-mGluR-2 Antibody (A-1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-mGluR-2 Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

mGluR-2 Antibody (A-1) Specifications

Alternate Product Name: mGluR-2

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 407-536

Epitope Target: mGluR-2

Epitope Species: human

Product Reactivity/Detection: mGluR-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for mGluR-2 Antibody (A-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred mGluR-2 antibody is mGluR-2 Antibody (A-7): sc-271655.