MAN2A1 Antibody (53FC3): sc-58312
- MAN2A1 Antibody (53FC3) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against liver golgi membranes of rat origin
- recommended for detection of MAN2A1 of mouse, rat and human origin by IF and IHC(P)
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MAN2A1 Antibody (53FC3) for IHC(P) applications. These reagents are now offered in bundles with MAN2A1 Antibody (53FC3) (see ordering information below).
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MAN2A1 Antibody (53FC3) is a mouse monoclonal IgG2b antibody that detects MAN2A1 in mouse, rat, and human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). MAN2A1, or mannosidase alpha class 2A member 1, is a crucial single-pass type II membrane protein predominantly located in the cisternae of the Golgi apparatus, where MAN2A1 plays a vital role in the modification of glycoproteins. MAN2A1 is essential for the proper processing of N-glycans, as MAN2A1 catalyzes the hydrolysis of terminal alpha-D-mannose residues in the oligosaccharide Man5(GlcNAc)3, a critical step in the formation of complex carbohydrates. MAN2A1 activity is zinc-dependent, highlighting the importance of metal cofactors in enzymatic reactions that facilitate protein maturation and function. Aberrations in MAN2A1 activity can lead to various glycosylation disorders, making MAN2A1 a significant target for research in cellular biology and disease mechanisms. Anti-MAN2A1 antibody (53FC3) is an invaluable tool for researchers investigating the roles of glycoproteins in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MAN2A1 Antibody (53FC3) References:
- The effects of swainsonine on the activity and expression of α-mannosidase in BRL-3A cells. | Lu, H., et al. 2015. Toxicon. 99: 44-50. PMID: 25797317
- MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice. | Chen, ZH., et al. 2017. Gastroenterology. 153: 1120-1132.e15. PMID: 28245430
- Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. | Yan, W., et al. 2018. Int J Mol Med. 42: 2776-2792. PMID: 30226535
- Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors. | Shi, S., et al. 2020. Clin Cancer Res. 26: 5990-6002. PMID: 32723834
- Possible immune regulation mechanisms for the progression of chronic thromboembolic pulmonary hypertension. | Miao, R., et al. 2021. Thromb Res. 198: 122-131. PMID: 33316641
- Homozygous truncating variant in MAN2A2 causes a novel congenital disorder of glycosylation with neurological involvement. | Mahajan, S., et al. 2023. J Med Genet. 60: 627-635. PMID: 36357165
- MAN2A1 predicts prognosis and progression through cancer-related pathways in colorectal cancer. | Wang, Y., et al. 2022. Transl Cancer Res. 11: 3686-3697. PMID: 36388015
- High-fat diet alters N-glycosylation of PTPRJ in murine liver. | Ulke, J., et al. 2024. J Nutr Biochem. 123: 109500. PMID: 37875230
- Immuno-targeting the ectopic phosphorylation sites of PDGFRA generated by MAN2A1-FER fusion in HCC. | Kader, M., et al. 2024. Hepatol Commun. 8: PMID: 39082961
- Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning. | Chen, J., et al. 2025. Front Mol Biosci. 12: 1529507. PMID: 39963268
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAN2A1 Antibody (53FC3) | sc-58312 | 200 µg/ml | $322.00 | |||
MAN2A1 Antibody (53FC3): m-IgG Fc BP-HRP Bundle | sc-537148 | 200 µg Ab; 10 µg BP | $361.00 | |||
MAN2A1 Antibody (53FC3): m-IgGκ BP-HRP Bundle | sc-534343 | 200 µg Ab; 40 µg BP | $361.00 | |||
MAN2A1 Antibody (53FC3): m-IgG2b BP-HRP Bundle | sc-549858 | 200 µg Ab; 10 µg BP | $361.00 |