LYSMD1 Antibody (G-11): sc-514282

LYSMD1 Antibody (G-11) is a mouse monoclonal IgG2a antibody that detects LYSMD1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LYSMD1, also known as SB145, is a 227 amino acid protein characterized by a single LysM repeat and exists in two alternatively spliced isoforms, which may play distinct roles in cellular processes. LYSMD1 is primarily located in the cytoplasm, where LYSMD1 is believed to be involved in the recognition and binding of peptidoglycan, a crucial component of bacterial cell walls. LYSMD1′s ability to interact with peptidoglycan suggests a role in the immune response, particularly in the detection and response to bacterial infections. Understanding LYSMD1 function could provide insights into potential therapeutic targets for infections and inflammatory conditions. The gene encoding LYSMD1 is situated on human chromosome 1, a region associated with various diseases, including certain cancers and genetic disorders, highlighting LYSMD1′s relevance in broader biological contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

LYSMD1 Antibody (G-11) References:

1. The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress.  |  Finelli, MJ., et al. 2016. J Biol Chem. 291: 2751-63. PMID: 26668325
2. In-Silico Characterization of a Hypothetical Protein, Rv1288 of Mycobacterium tuberculosis Containing an Esterase Signature and an Uncommon LytE Domain.  |  Kumar, A., et al. 2017. Curr Comput Aided Drug Des. 13: 101-111. PMID: 27890013
3. Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome.  |  Sano, S., et al. 2018. J Am Coll Cardiol. 71: 875-886. PMID: 29471939
4. Expression profiling in a mammalian host reveals the strong induction of genes encoding LysM domain-containing proteins in Enterococcus faecium.  |  Cacaci, M., et al. 2018. Sci Rep. 8: 12412. PMID: 30120332
5. Identification of the RNA-binding domain-containing protein RbpA that acts as a global regulator of the pathogenicity of Streptococcus suis serotype 2.  |  Zhong, X., et al. 2022. Virulence. 13: 1304-1314. PMID: 35903019
6. Fungal dual-domain LysM effectors undergo chitin-induced intermolecular, and not intramolecular, dimerization.  |  Tian, H., et al. 2022. Plant Physiol. 190: 2033-2044. PMID: 35997573
7. Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes.  |  Wang, YT., et al. 2023. Autophagy. 19: 1114-1127. PMID: 36056542
8. TLDc Domain-Containing Genes in Autism Spectrum Disorder: New Players in the Oxidative Stress Response.  |  Zucchini, C., et al. 2023. Int J Mol Sci. 24: PMID: 37958785
9. Cell-free hemoglobin triggers macrophage cytokine production via TLR4 and MyD88.  |  Schaaf, KR., et al. 2024. Am J Physiol Lung Cell Mol Physiol. 326: L29-L38. PMID: 37991487
10. LYSMD proteins promote activation of Rab32-family GTPases for lysosome-related organelle biogenesis.  |  Li, J., et al. 2024. J Cell Biol. 223: PMID: 39078368

The preferred LYSMD1 antibody is LYSMD1 Antibody (G-3): sc-514030.