LOX Antibody (B-11): sc-514757

LOX Antibody (B-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects LOX protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LOX antibody (B-11) is available as the non-conjugated form. The lysyl oxidase family, which includes LOX and four LOX-like enzymes, plays a critical role in the extracellular matrix by catalyzing the oxidative deamination of peptidyl lysine residues in collagens and elastin, leading to the formation of cross-links that provide structural integrity to tissues. This function is particularly important as LOX contributes to the mechanical properties of connective tissues, influencing their strength and elasticity. Dysregulation of LOX activity can result in pathological conditions, such as fibrosis, where excessive cross-linking leads to tissue stiffness and impaired function. LOX is essential for normal cardiovascular and respiratory system development, and LOX expression is intricately linked to processes such as wound healing, cell motility, and differentiation. Alterations in LOX levels have also been associated with skin aging and senescence, highlighting LOX significance in both developmental biology and age-related diseases.

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LOX Antibody (B-11) References:

1. Regulation of COX and LOX by curcumin.  |  Rao, CV. 2007. Adv Exp Med Biol. 595: 213-26. PMID: 17569213
2. A new role for LOX and LOXL2 proteins in transcription regulation.  |  Iturbide, A., et al. 2015. FEBS J. 282: 1768-73. PMID: 25103872
3. Thiazoles and Thiazolidinones as COX/LOX Inhibitors.  |  Liaras, K., et al. 2018. Molecules. 23: PMID: 29562646
4. Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment.  |  Amendola, PG., et al. 2019. Cancers (Basel). 11: PMID: 31130685
5. Screening for Novel LOX and SOD1 Variants in Keratoconus Patients from Brazil.  |  Gadelha, DNB., et al. 2020. J Ophthalmic Vis Res. 15: 138-148. PMID: 32308947
6. Lysyl Oxidase (LOX): Functional Contributions to Signaling Pathways.  |  Laczko, R. and Csiszar, K. 2020. Biomolecules. 10: PMID: 32708046
7. Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin.  |  Lin, W., et al. 2023. Biomed Pharmacother. 166: 115394. PMID: 37660647
8. A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer.  |  Cetin, M., et al. 2024. Cell Chem Biol. 31: 1926-1941.e11. PMID: 39043186
9. Lysyl Oxidase (LOX) Family Proteins: Key Players in Breast Cancer Occurrence and Progression.  |  Li, J., et al. 2024. J Cancer. 15: 5230-5243. PMID: 39247609
10. LOX-mediated ECM mechanical stress induces Piezo1 activation in hypoxic-ischemic brain damage and identification of novel inhibitor of LOX.  |  Jiang, D., et al. 2024. Redox Biol. 76: 103346. PMID: 39260063

The preferred LOX antibody is LOX Antibody (F-8): sc-373995.