LOX Activators
LOX activators, short for Lysyl oxidase activators, represent a class of chemical compounds that play a pivotal role in modulating the activity of the enzyme lysyl oxidase (LOX). Lysyl oxidase is a copper-dependent enzyme found in various tissues throughout the human body, including the skin, blood vessels, and connective tissues. Its primary function is the catalysis of oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, two essential components of the extracellular matrix. This enzymatic reaction is a crucial step in the formation and maintenance of the structural integrity of these proteins, ensuring the strength and stability of connective tissues.
LOX activators are chemical compounds that can stimulate the activity of lysyl oxidase. By doing so, they contribute to the cross-linking and stabilization of collagen and elastin fibers, thereby enhancing the overall structural integrity of the extracellular matrix. This process is fundamental in various physiological and pathological contexts, such as tissue development, wound healing, and tissue remodeling. In essence, LOX activators function as molecular switches that promote the enzymatic activity of LOX, facilitating the formation of stable collagen and elastin cross-links, which, in turn, affect tissue strength and elasticity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
As an essential nutrient, Vitamin C plays a role in collagen synthesis. It is required for the proper function of LOX, and its supplementation has been shown to enhance LOX activity. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper is a crucial cofactor for LOX. Copper sulfate supplementation can enhance LOX activity and stability, ensuring proper collagen and elastin cross-linking. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
As a form of estrogen, β-Estradiol has been shown to modulate LOX expression. It plays a role in maintaining skin elasticity and wound healing. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid. It has been reported to increase LOX expression in certain cell types, influencing tissue remodeling and repair. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of Vitamin A, is involved in cell differentiation and proliferation. It has been shown to upregulate LOX expression, participating in skin regeneration and fibrosis. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As a reactive oxygen species, hydrogen peroxide can influence cell signaling pathways. It has been implicated in the upregulation of LOX, contributing to tissue repair and fibrotic responses. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
High glucose levels have been reported to induce LOX expression. This is relevant in diabetic conditions, contributing to the increased risk of fibrotic complications. | ||||||