Liprin α1 Antibody (A-5): sc-376141

Liprin α1 Antibody (A-5) is a mouse monoclonal IgG2b antibody that detects Liprin α1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Liprin α1 is a crucial component in cellular signaling, particularly in axon guidance and mammary gland development, as Liprin α1 interacts with members of the leukocyte common antigen-related (LAR) family of transmembrane protein tyrosine phosphatases. This interaction is vital for forming complex structures that serve as scaffolds, facilitating the recruitment and anchoring of LAR phosphatases. Liprin α1 is predominantly located in the cytoplasm and at the plasma membrane, where Liprin α1 plays a significant role in regulating cell migration and potentially preventing metastasis through interaction with the tumor suppressor ING4. Notably, Liprin α1 function can be modulated by post-translational modifications, such as phosphorylation, which can influence binding affinity and stability. Anti-Liprin α1 antibody (A-5) is an essential tool for researchers investigating the molecular mechanisms underlying cell signaling and migration, providing insights into liprin roles in various biological processes.

The preferred Liprin α1 antibody is Liprin α1 Antibody (A-6): sc-398030.