Liprin α1 Antibody (A-6): sc-398030
- Liprin α1 Antibody (A-6) is a mouse monoclonal IgM κ Liprin α1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 522-541 within an internal region of Liprin α1 of human origin
- recommended for detection of Liprin α1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Liprin α1 Antibody (A-6). This work is in progress.
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Liprin α1 Antibody (A-6) is a mouse monoclonal IgM antibody that detects Liprin alpha 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Liprin alpha 1 antibody (A-6) is available as a non-conjugated format. Liprin alpha 1 plays a crucial role in cellular signaling and organization, particularly in the nervous system, where Liprin alpha 1 is involved in regulating synaptic development and plasticity. Liprin alpha 1 is primarily located at the postsynaptic density, serving as a scaffold for various signaling molecules, thereby facilitating the assembly of protein complexes essential for synaptic function. Proper localization of Liprin alpha 1 is vital for maintaining synaptic integrity and ensuring effective communication between neurons, which is fundamental for learning and memory processes. Liprin alpha 1 interacts with tumor suppressor ING4, influencing cell migration and potentially preventing metastasis, highlighting Liprin alpha 1′s importance in both neural and cancer biology. Liprin alpha 1′s interaction with members of the leukocyte common antigen-related family of transmembrane protein tyrosine phosphatases further underscores Liprin alpha 1′s role in critical developmental processes, such as axon guidance and mammary gland development.
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Liprin α1 Antibody (A-6) References:
- Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis. | Kaufmann, N., et al. 2002. Neuron. 34: 27-38. PMID: 11931739
- Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. | Ko, J., et al. 2003. J Neurosci. 23: 1667-77. PMID: 12629171
- Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex. | Olsen, O., et al. 2006. Curr Opin Cell Biol. 18: 223-7. PMID: 16504495
- Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting. | Hofmeyer, K., et al. 2006. Proc Natl Acad Sci U S A. 103: 11595-600. PMID: 16864797
- Liprin-alpha is required for photoreceptor target selection in Drosophila. | Choe, KM., et al. 2006. Proc Natl Acad Sci U S A. 103: 11601-6. PMID: 16864799
- Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. | Unoki, M., et al. 2006. J Biol Chem. 281: 34677-86. PMID: 16973615
- Hierarchical assembly of presynaptic components in defined C. elegans synapses. | Patel, MR., et al. 2006. Nat Neurosci. 9: 1488-98. PMID: 17115039
- Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1. | Shen, JC., et al. 2007. Cancer Res. 67: 2552-8. PMID: 17363573
- Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. | Serra-Pagès, C., et al. 1998. J Biol Chem. 273: 15611-20. PMID: 9624153
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Liprin α1 Antibody (A-6) | sc-398030 | 200 µg/ml | $316.00 | |||
Liprin α1 (A-6) Neutralizing Peptide | sc-398030 P | 100 µg/0.5 ml | $68.00 |