Lefty Antibody (F-11): sc-166708

Lefty Antibody (F-11) is a mouse monoclonal IgG2b antibody that detects Lefty in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Lefty antibody (F-11) specifically targets Lefty, a crucial member of the TGFβ superfamily, which plays a significant role in embryonic development and adult tissue homeostasis. Lefty is primarily secreted and essential for establishing left-right asymmetry during organ development in mammals, particularly influencing heart and lung formation. Lefty is predominantly expressed in the prospective floor plate of developing embryos, with additional expression noted in the lateral-plate mesoderm. Proper functioning of Lefty is vital, as mutations in Lefty can lead to severe left-right axis malformations, resulting in congenital heart defects and other organ system abnormalities. Dysregulation of Lefty expression has been linked to certain types of infertility, particularly due to its role in endometrial bleeding. Lefty (F-11) antibody serves as an invaluable tool for researchers studying developmental biology, congenital disorders, and reproductive health, providing insights into the complex mechanisms governing left-right asymmetry and its implications in various pathologies.

The preferred Lefty antibody is Lefty Antibody (D-6): sc-365845.