LCOR Antibody (G-2): sc-515633

LCOR Antibody (G-2) is a mouse monoclonal IgG2b antibody that detects LCOR (Ligand-dependent corepressor) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LCOR is a 433 amino acid transcriptional corepressor characterized by its LXXLL motif, nuclear localization signal, and helix-loop-helix domain, which are crucial for regulating gene expression. LCOR is predominantly expressed in both fetal and adult tissues, where LCOR plays a vital role in modulating the activity of nuclear receptors, particularly estrogen receptors ERα and ERβ, in the presence of estradiol. By acting as a molecular scaffold, LCOR facilitates the recruitment of transcriptional repression proteins to DNA, thereby influencing the transcriptional landscape in response to hormonal signals. Notably, LCOR′s activity is subject to inhibition by the histone deacetylase inhibitor trichostatin A, indicating a complex interplay with histone modifications that underscores LCOR′s role in a negative feedback loop to attenuate hormone-induced transactivation. Anti-LCOR antibody (G-2) is an essential tool for researchers investigating the intricate mechanisms of transcriptional regulation and the impact of hormonal signaling in various biological contexts.

The preferred LCOR antibody is LCOR Antibody (C-6): sc-377019.