LCOR Antibody (C-6): sc-377019

LCOR Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects LCOR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). LCOR (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LCOR protein, also known as Ligand-dependent corepressor or MLR2, is a 433 amino acid transcriptional corepressor characterized by an LXXLL motif, a nuclear localization signal, and a helix-loop-helix domain. LCOR protein is crucial for regulating gene expression as LCOR is widely expressed in both fetal and adult tissues, where LCOR plays a significant role in mediating the effects of nuclear receptors. LCOR interacts with several estrogen receptors, including ERα and ERβ, in the presence of estradiol, thereby functioning as a molecular scaffold that recruits proteins involved in transcriptional repression to the DNA. LCOR′s structure facilitates these interactions, which are essential for maintaining hormonal balance and regulating transcriptional activity. LCOR′s activity is modulated by the histone deacetylase inhibitor trichostatin A, indicating a receptor-dependent mechanism of action that contributes to LCOR′s role in negative feedback loops to diminish hormone-induced transactivation.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

LCOR Antibody (C-6) References:

1. Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms.  |  Fernandes, I., et al. 2003. Mol Cell. 11: 139-50. PMID: 12535528
2. Agonist-bound nuclear receptors: not just targets of coactivators.  |  Fernandes, I. and White, JH. 2003. J Mol Endocrinol. 31: 1-7. PMID: 12914520
3. The role of corepressors in transcriptional regulation by nuclear hormone receptors.  |  Privalsky, ML. 2004. Annu Rev Physiol. 66: 315-60. PMID: 14977406
4. Corepressor recruitment by agonist-bound nuclear receptors.  |  White, JH., et al. 2004. Vitam Horm. 68: 123-43. PMID: 15193453
5. Coactivators and corepressors as mediators of nuclear receptor function: an update.  |  Jenster, G. 1998. Mol Cell Endocrinol. 143: 1-7. PMID: 9806345

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LCOR Antibody (C-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LCOR Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LCOR Antibody (C-6) Specifications

Alternate Product Name: LCOR

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 87-281

Epitope Target: LCOR

Epitope Species: human

Product Reactivity/Detection: LCOR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LCOR Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin