Laminin γ-2 Antibody (B-2): sc-25341

Laminin γ-2 Antibody (B-2) is a mouse monoclonal IgG2a antibody that detects Laminin γ-2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Laminin γ-2 is a crucial component of basement membranes, which are specialized extracellular matrices that provide structural support to tissues and play a vital role in cellular functions. These membranes are not only essential for maintaining tissue architecture but also influence key processes such as cell proliferation, migration, and differentiation. The unique structure of Laminin γ-2, which consists of a heterotrimer formed by α, β, and γ chain subunits, allows for self-assembly and interaction with other matrix components, facilitating the formation of stable basement membranes. Laminin γ-2 interacts with various cell surface receptors, including integrins and dystroglycan, which mediate cellular signaling and adhesion. The human Laminin γ-2 gene is located on chromosome 1q25-q31 and is predominantly expressed in epithelial cells of the skin, lung, and kidney, highlighting its significance in maintaining the integrity and function of these tissues. Anti-Laminin γ-2 antibody (B-2) is an invaluable tool for researchers studying the dynamics of basement membranes and their impact on cellular behavior in health and disease.

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Laminin γ-2 Antibody (B-2) References:

1. Laminin gamma2 chain as a stromal cell marker of the human bone marrow microenvironment.  |  Siler, U., et al. 2002. Br J Haematol. 119: 212-20. PMID: 12358928
2. The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain.  |  Ogawa, T., et al. 2007. Mol Biol Cell. 18: 1621-33. PMID: 17314405
3. Aberrant expression of laminin γ2 correlates with poor prognosis and promotes invasion in extrahepatic cholangiocarcinoma.  |  Liu, W., et al. 2014. J Surg Res. 186: 150-6. PMID: 24124977
4. Laminin γ2 knockout mice rescued with the human protein exhibit enamel maturation defects.  |  Wazen, RM., et al. 2016. Matrix Biol. 52-54: 207-218. PMID: 26956061
5. Unique Biological Activity and Potential Role of Monomeric Laminin-γ2 as a Novel Biomarker for Hepatocellular Carcinoma: A Review.  |  Yasuda, H., et al. 2019. Int J Mol Sci. 20: PMID: 30626121
6. Serum Laminin γ2 Monomer as a Diagnostic and Predictive Biomarker for Hepatocellular Carcinoma.  |  Yamashita, T., et al. 2021. Hepatology. 74: 760-775. PMID: 33609304
7. Clinical evaluation of urine laminin-γ2 monomer as a potent biomarker for non-muscle invasive bladder cancer.  |  Karashima, T., et al. 2023. Cancer Med. 12: 2453-2462. PMID: 35924681
8. Activation of Laminin γ2 by Helicobacter pylori Promotes Invasion and Survival of Gastric Cancer Cells With E-Cadherin Defects.  |  Ferreira, RM., et al. 2022. J Infect Dis. 226: 2226-2237. PMID: 36173814
9. Invasion-Associated Reorganization of Laminin 332 in Oral Squamous Cell Carcinomas: The Role of the Laminin γ2 Chain in Tumor Biology, Diagnosis, and Therapy.  |  Berndt, A., et al. 2022. Cancers (Basel). 14: PMID: 36230826
10. Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study.  |  Nio, K., et al. 2024. Sci Rep. 14: 25395. PMID: 39455696

The preferred Laminin γ-2 antibody is Laminin γ-2 Antibody (E-6): sc-28330.