Laminin γ-2 Inhibitors
Laminin γ-2 inhibitors constitute a distinctive class of chemical entities meticulously designed to exert their effects on laminin γ-2, a pivotal protein integral to the extracellular matrix (ECM). The ECM, a complex network of macromolecules, serves as a foundational scaffold for diverse tissues and organs within the human body. Laminins, a family of glycoproteins within the ECM, contribute significantly to the structural integrity of tissues. Laminin γ-2, a specific subunit of laminin-332 located in the basement membrane, assumes a crucial role in cellular adhesion and the preservation of tissue integrity. The strategic design of laminin γ-2 inhibitors involves the intentional disruption of this protein's functionality, with the aim of interfering with its interactions with other ECM constituents and cellular receptors.
Laminin γ-2 inhibitors, conceived primarily for investigative purposes, emerge as invaluable tools in the realm of scientific exploration. Notably, these inhibitors offer researchers a means to dissect the multifaceted contributions of laminin γ-2 in fundamental biological phenomena such as tissue development, wound healing, and the metastatic progression of cancer. The specificity of laminin γ-2 inhibition enables researchers to unravel the complexities inherent in the cross-talk between ECM components and cellular behaviors, paving the way for a more nuanced understanding of the intricate molecular interplay that underlies various physiological and pathological processes. In essence, the deliberate interference with laminin γ-2 through these inhibitors serves as a powerful investigative approach, affording researchers unprecedented opportunities to probe the nuanced intricacies of cell-matrix interactions and their ramifications across diverse biological contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin can potentially show the inhibition of cyclooxygenase enzymes and the subsequent modulation of gene expression, including the downregulation of laminin γ-2. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride can potentially show activation of AMP-activated protein kinase (AMPK) and the subsequent inhibition of the mTOR pathway, which could lead to the downregulation of laminin γ-2 and other proteins involved in cell proliferation and survival. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin works by inhibiting the mTOR pathway, a key regulator of cell growth and survival. Through this mechanism, rapamycin has the potential to downregulate the expression of laminin γ-2 and other proteins. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a metabolite of vitamin A and is known for its role in cell growth, differentiation, and apoptosis. Studies have shown that retinoic acid can modulate gene expression and potentially inhibit the expression of laminin γ-2 and other proteins involved in tumor progression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can possibly show the inhibition of the proteasome and NF-κB pathway, which may lead to the downregulation of laminin γ-2 and other proteins involved in cell survival and invasion. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Itraconazole can inhibit angiogenesis and the Hedgehog signaling pathway, potentially leading to the downregulation of laminin γ-2 and other proteins associated with tumor growth and metastasis. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor that can possibly induce cell death through the downregulation of laminin γ-2 and other proteins involved in cell survival and invasion. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analog that has demonstrated certain effects, possibly through its ability to induce DNA demethylation and reactivate tumor suppressor genes, leading to the downregulation of laminin γ-2 and other proteins. | ||||||
Nelfinavir | 159989-64-7 | sc-507314 | 10 mg | $168.00 | ||
Nelfinavir studies have suggested that it may potentially inhibit the proteasome and inducing endoplasmic reticulum stress, leading to the downregulation of laminin γ-2 and other proteins involved in cell survival. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Research has suggested that thalidomide may inhibit tumor growth and angiogenesis, potentially through the downregulation of laminin γ-2 and other proteins involved in tumor progression. | ||||||