Laminin γ-2 Antibody (E-6): sc-28330

Laminin γ-2 Antibody (E-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Laminin γ-2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Laminin γ-2 antibody (E-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Laminin γ-2 plays a crucial role in forming and maintaining basement membranes, which are specialized extracellular matrices that provide structural support to tissues and influence cellular behaviors such as proliferation, migration, and differentiation. These basement membranes contain Laminin γ-2, a heterotrimer formed by the assembly of α, β, and γ chain subunits. Proper assembly and function of Laminin γ-2 are vital for tissue integrity and function, as Laminin γ-2 interacts with various cell surface receptors, including integrins and dystroglycan, to mediate cell adhesion and signaling. The human Laminin γ-2 gene is located on chromosome 1q25-q31 and is predominantly expressed in epithelial cells of the skin, lung, and kidney, highlighting its importance in maintaining the structural and functional integrity of these tissues.

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Laminin γ-2 Antibody (E-6) References:

1. Role of laminin isoforms in glomerular structure.  |  Hansen, K. and Abrass, CK. 1999. Pathobiology. 67: 84-91. PMID: 10023136
2. Form and function: the laminin family of heterotrimers.  |  Colognato, H. and Yurchenco, PD. 2000. Dev Dyn. 218: 213-34. PMID: 10842354
3. Transcriptional regulation of laminin gene expression.  |  Aberdam, D., et al. 2000. Microsc Res Tech. 51: 228-37. PMID: 11054873
4. Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma.  |  Patel, V., et al. 2002. Int J Cancer. 99: 583-8. PMID: 11992550
5. Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells.  |  Yamamoto, H., et al. 2009. Gastroenterology. 137: 242-52, 252.e1-6. PMID: 19582886
6. Urinary laminin-γ2 is a novel biomarker of non-muscle invasive urothelial carcinoma.  |  Kamada, M., et al. 2015. Cancer Sci. 106: 1730-7. PMID: 26450632
7. Expression and localization of amelotin, laminin γ2 and odontogenesis-associated phosphoprotein (ODAPH) on the basal lamina and junctional epithelium.  |  Li, C., et al. 2022. J Mol Histol. 53: 111-118. PMID: 34709488
8. The laminin family.  |  Tryggvason, K. 1993. Curr Opin Cell Biol. 5: 877-82. PMID: 8240830
9. Role of laminin in endothelial cell recognition and differentiation.  |  Schnaper, HW., et al. 1993. Kidney Int. 43: 20-5. PMID: 8433560
10. Domains of laminin.  |  Engvall, E. and Wewer, UM. 1996. J Cell Biochem. 61: 493-501. PMID: 8806072
11. Laminin and the mechanism of neuronal outgrowth.  |  Luckenbill-Edds, L. 1997. Brain Res Brain Res Rev. 23: 1-27. PMID: 9063584
12. Laminin isoforms and epithelial development.  |  Ekblom, M., et al. 1998. Ann N Y Acad Sci. 857: 194-211. PMID: 9917842

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Laminin γ-2 Antibody (E-6) has 35 citations in a variety of scientific publications.

Primary antibodies like Anti-Laminin γ-2 Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Laminin γ-2 Antibody (E-6) Specifications

Alternate Product Name: Laminin γ-2

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1011-1193

Epitope Target: Laminin γ-2

Epitope Species: human

Product Reactivity/Detection: Laminin γ-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 35 citations in various scientific publications

Available Conjugates/Forms for Laminin γ-2 Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin