Laminin β-1 Antibody (D-9): sc-17763

Laminin β-1 Antibody (D-9) is a mouse monoclonal IgG2a light chain antibody that detects Laminin β-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Laminin β-1 plays a crucial role in the formation and maintenance of basement membranes, which are specialized extracellular matrices that provide structural support to tissues and influence cellular behaviors such as proliferation, migration, and differentiation. The protein is a heterotrimer composed of α, β, and γ chain subunits, which allows for self-assembly and interaction with other matrix components, thereby contributing to the integrity and functionality of the extracellular environment. Laminin β-1 interacts with various cell surface receptors, including integrins and dystroglycan, facilitating cell adhesion and signaling pathways that are vital for tissue homeostasis. The human Laminin β-1 gene is located on chromosome 7q22 and is widely expressed in tissues that produce basement membranes, underscoring its significance in both normal physiology and pathological conditions. Anti-Laminin β-1 antibody (D-9) is an invaluable tool for researchers studying the dynamics of basement membrane biology and its implications in diseases such as cancer and fibrosis.

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Laminin β-1 Antibody (D-9) References:

1. Monoclonal anti-mouse laminin antibodies: AL-1 reacts with laminin alpha1 chain, AL-2 with laminin beta1 chain, and AL-4 with the coiled-coil domain of laminin beta1 chain.  |  Schéele, S., et al. 2006. Matrix Biol. 25: 301-5. PMID: 16631359
2. Expression of laminin beta1 in hippocampi of patients with intractable epilepsy.  |  Wu, Y., et al. 2008. Neurosci Lett. 443: 160-4. PMID: 18691630
3. A novel disulfide pattern in laminin-type epidermal growth factor-like (LE) modules of laminin β1 and γ1 chains.  |  Kalkhof, S., et al. 2010. Biochemistry. 49: 8359-66. PMID: 20731416
4. Laminin/β1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization.  |  Lei, WL., et al. 2012. Cell Res. 22: 954-72. PMID: 22430151
5. Analysis of colorectal cancer glyco-secretome identifies laminin β-1 (LAMB1) as a potential serological biomarker for colorectal cancer.  |  Lin, Q., et al. 2015. Proteomics. 15: 3905-20. PMID: 26359947
6. Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report.  |  Wagner, JUG., et al. 2018. Arterioscler Thromb Vasc Biol. 38: 1170-1177. PMID: 29599141
7. Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice.  |  Li, ZZ., et al. 2021. J Clin Invest. 131: PMID: 34156983
8. The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1.  |  Noakes, PG., et al. 1995. Nat Genet. 10: 400-6. PMID: 7670489
9. Laminin and heparan sulfate proteoglycan mediate epithelial cell polarization in organotypic cultures of embryonic lung cells: evidence implicating involvement of the inner globular region of laminin beta 1 chain and the heparan sulfate groups of heparan sulfate proteoglycan.  |  Schuger, L., et al. 1996. Dev Biol. 179: 264-73. PMID: 8873769
10. Abnormal expression of laminin beta 1 chain in skeletal muscle of adult-onset limb-girdle muscular dystrophy.  |  Li, M., et al. 1997. Arch Neurol. 54: 1457-61. PMID: 9400354

The preferred Laminin β-1 antibody is Laminin β-1 Antibody (LT3): sc-33709.