L-Selectin/CD62L/SELL Antibody (DREG55): sc-18905
- L-Selectin/CD62L/SELL Antibody (DREG55) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against human peripheral blood leukocytes induced with PMA
- recommended for detection of L-Selectin of human origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for L-Selectin/CD62L/SELL Antibody (DREG55). These reagents are now offered in bundles with L-Selectin/CD62L/SELL Antibody (DREG55) (see ordering information below).
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L-Selectin Antibody (DREG55) is a mouse monoclonal IgG1 antibody that detects L-Selectin in human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. L-Selectin, also known as LECAM-1 or CD62L, plays a crucial role in the immune response by facilitating the adhesion of leukocytes to the endothelium, which is essential for the migration of immune cells to sites of inflammation or injury. L-Selectin is predominantly expressed on the surface of naive T cells, B cells, and various types of leukocytes, including monocytes, neutrophils, and eosinophils. L-Selectin′s ability to interact with specific carbohydrates on activated endothelial cells is vital for the initial steps of leukocyte recruitment, making L-Selectin a key player in the inflammatory response. Furthermore, L-Selectin′s interactions with other selectins, such as P-Selectin and E-Selectin, highlight L-Selectin′s importance in mediating complex cellular interactions during immune responses. Anti-L-Selectin antibody (DREG55) is an invaluable tool for researchers studying immune cell dynamics and the mechanisms underlying inflammation and immune regulation.
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L-Selectin/CD62L/SELL Antibody (DREG55) References:
- Up-regulation of L-selectin and E-selectin in hypersensitivity pneumonitis. | Navarro, C., et al. 2002. Chest. 121: 354-60. PMID: 11834643
- L-selectin: an emerging player in chemokine function. | Khan, AI. and Kubes, P. 2003. Microcirculation. 10: 351-8. PMID: 12851651
- L-selectin and skin damage in systemic sclerosis. | Dunne, JV., et al. 2012. PLoS One. 7: e44814. PMID: 23028631
- L-selectin ligands expression in human fallopian tube epithelia of tubal pregnancies. | Li, S., et al. 2014. Biol Reprod. 90: 133. PMID: 24829027
- L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. | Rzeniewicz, K., et al. 2015. Proc Natl Acad Sci U S A. 112: E1461-70. PMID: 25775539
- HIV-1 targets L-selectin for adhesion and induces its shedding for viral release. | Kononchik, J., et al. 2018. Nat Commun. 9: 2825. PMID: 30026537
- Impact of real-time shedding on binding kinetics of membrane-remaining L-selectin to PSGL-1. | Peng, S., et al. 2019. Am J Physiol Cell Physiol. 316: C678-C689. PMID: 30726114
- ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. | Mohammed, RN., et al. 2019. Sci Rep. 9: 5487. PMID: 30940840
- L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men. | Drescher, HK., et al. 2020. Cells. 9: PMID: 32365632
- L-selectin-mediated lymphocyte rolling on MAdCAM-1. | Berg, EL., et al. 1993. Nature. 366: 695-8. PMID: 7505053
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Selectin/CD62L/SELL Antibody (DREG55) | sc-18905 | 200 µg/ml | $322.00 | |||
L-Selectin/CD62L/SELL Antibody (DREG55): m-IgG Fc BP-HRP Bundle | sc-536613 | 200 µg Ab; 10 µg BP | $361.00 | |||
L-Selectin/CD62L/SELL Antibody (DREG55): m-IgGκ BP-HRP Bundle | sc-533769 | 200 µg Ab; 40 µg BP | $361.00 | |||
L-Selectin/CD62L/SELL Antibody (DREG55): m-IgG1 BP-HRP Bundle | sc-544708 | 200 µg Ab; 20 µg BP | $361.00 | |||
L-Selectin/CD62L/SELL Antibody (DREG55) FITC | sc-18905 FITC | 200 µg/ml | $336.00 | |||
L-Selectin/CD62L/SELL Antibody (DREG55) PE | sc-18905 PE | 200 µg/ml | $349.00 |