Ku70 Antibody (S5C11): sc-56130
- Ku70 Antibody (S5C11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against placental cell extract of human origin
- recommended for detection of Ku70 of human origin by WB, IP, IF and IHC(P)
- See Ku70 (E-5): sc-17789 for Ku70 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Ku70 Antibody (S5C11) for WB and IHC(P) applications. These reagents are now offered in bundles with Ku70 Antibody (S5C11) (see ordering information below).
Ku70 Antibody (S5C11) is a mouse monoclonal IgG1 antibody that detects Ku70 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Ku70 is a critical component of the Ku protein complex, which is essential for DNA repair and maintenance of genomic stability. Ku70 is primarily located in the nucleus, where Ku70 plays a vital role in recognizing and binding to double-strand breaks in DNA, thereby facilitating the recruitment of other repair factors. The importance of Ku70′s nuclear localization cannot be overstated, as Ku70 ensures ready availability to respond to DNA damage, which is crucial for preventing mutations and maintaining cellular integrity. Additionally, Ku70 interacts with its partner subunit, Ku86, to form a heterodimer that is integral to the non-homologous end joining (NHEJ) pathway of DNA repair. This pathway is particularly important in the context of cellular responses to genotoxic stress, making Ku70 a key player in the preservation of genetic information and the prevention of cancerous transformations. With diverse roles in DNA repair and transcriptional regulation, Ku70 is a significant target for research in cancer biology and therapeutic interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ku70 Antibody (S5C11) | sc-56130 | 200 µg/ml | $316.00 | |||
Ku70 Antibody (S5C11): m-IgG Fc BP-HRP Bundle | sc-537096 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ku70 Antibody (S5C11): m-IgGκ BP-HRP Bundle | sc-534286 | 200 µg Ab; 40 µg BP | $354.00 | |||
Ku70 Antibody (S5C11): m-IgG1 BP-HRP Bundle | sc-545000 | 200 µg Ab; 20 µg BP | $354.00 |