IL-4 Antibody (HIL41): sc-12723
- IL-4 Antibody (HIL41) is a mouse monoclonal IgG2b κ IL-4 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against full length IL-4 of human origin
- IL-4 Antibody (HIL41) is recommended for detection of IL-4 of human origin by WB, IP, IF and ELISA
- See IL-4 (HIL44): sc-13555 for IL-4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for IL-4 Antibody (HIL41) for WB applications. This reagent is now offered in a bundle with IL-4 Antibody (HIL41) (see ordering information below).
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IL-4 Antibody (HIL41) is a mouse monoclonal IgG2b kappa light chain antibody that detects the IL-4 protein of human origin by WB, IP, IF, and ELISA. IL-4 Antibody (HIL41) is available in both non-conjugated and various conjugated forms, including agarose, HRP, PE, FITC, and multiple Alexa Fluor® conjugates. Interleukin-4 (IL-4), also known as B cell stimulatory factor-1, is a glycosylated cytokine secreted primarily by activated T lymphocytes, basophils, and mast cells. IL-4 plays a crucial role in the immune system by promoting the growth and differentiation of immune cells, particularly by enhancing the Th2 cell lineage while inhibiting Th1 cell development. The balance between these T helper cell subsets is vital for orchestrating appropriate immune responses; Th1 cells are associated with pro-inflammatory responses, while Th2 cells are involved in allergic reactions and responses to parasitic infections. Additionally, IL-4 is essential for immunoglobulin class switching, specifically inducing the production of IgE and enhancing IgG4 secretion by B cells, while suppressing the production of other immunoglobulin classes such as IgM, IgA, IgG1, IgG2, and IgG3. Notably, the signaling pathway activated by IL-4 involves the rapid tyrosine phosphorylation of Stat6, which is a critical step in mediating effects on immune cell function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-4 Antibody (HIL41) References:
- Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13. | Gao, S., et al. 2015. J Mol Cell Cardiol. 85: 131-9. PMID: 25944087
- Functions of IL-4 and Control of Its Expression. | Brown, MA. and Hural, J. 2017. Crit Rev Immunol. 37: 181-212. PMID: 29773020
- IL-4-polarized BV2 microglia cells promote angiogenesis by secreting exosomes. | Tian, Y., et al. 2019. Adv Clin Exp Med. 28: 421-430. PMID: 30684318
- Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer. | Shi, J., et al. 2021. Int J Mol Sci. 22: PMID: 33804263
- IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity. | Phu, TA., et al. 2022. Mol Ther. 30: 2274-2297. PMID: 35292359
- IL-13/IL-4 signaling contributes to fibrotic progression of the myeloproliferative neoplasms. | Melo-Cardenas, J., et al. 2022. Blood. 140: 2805-2817. PMID: 36283106
- Induction of unique macrophage subset by simultaneous stimulation with LPS and IL-4. | Ishida, K., et al. 2023. Front Immunol. 14: 1111729. PMID: 37180123
- IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development. | Guedes, JR., et al. 2023. Neuron. 111: 3435-3449.e8. PMID: 37918358
- An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. | LaMarche, NM., et al. 2024. Nature. 625: 166-174. PMID: 38057662
- Ovarian cancer-derived IL-4 promotes immunotherapy resistance. | Mollaoglu, G., et al. 2024. Cell. 187: 7492-7510.e22. PMID: 39481380
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-4 Antibody (HIL41) | sc-12723 | 200 µg/ml | $322.00 | |||
IL-4 Antibody (HIL41): m-IgG Fc BP-HRP Bundle | sc-525460 | 200 µg Ab; 10 µg BP | $361.00 |