IFN-γ/Interferon gamma Antibody (3F1E3): sc-32813

IFN-γ Antibody (3F1E3) is a mouse monoclonal IgG1 antibody that detects Interferon (IFN)-γ in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). IFN-γ plays a crucial role in the immune response, acting as an antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. Production of IFN-γ is stimulated by various factors, including antigens, mitogens, and alloantigens, and proves essential for modulating T cell growth and differentiation while inhibiting B cell proliferation. IFN-γ′s active form is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the helices′ interface. The significance of IFN-γ′s structure lies in its ability to effectively bind to its receptor, initiating a cascade of immune responses vital for combating infections and regulating immune functions. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and IFN-γ′s functionality is further diversified by variable glycosylation and the formation of dimers and tetramers under non-denaturing conditions. With a critical role in immune regulation and response, anti-IFN-γ antibody (3F1E3) serves as an invaluable tool for researchers studying immune mechanisms and therapeutic interventions.

The preferred IFN-γ/Interferon gamma antibody is IFN-γ/Interferon gamma Antibody (G-23): sc-8423.