IFN-γ Activators
Common IFN-γ Activators include, but are not limited to Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, Polyinosinic-polycytidylic acid potassium salt CAS 31852-29-6, PMA CAS 16561-29-8, Zymosan A from Saccharomyces cerevisiae CAS 58856-93-2 and Imiquimod CAS 99011-02-6.
Interferon-gamma (IFN-γ) is a type II interferon that plays a pivotal role in the immune response against viral infections and tumor control. Its expression is influenced by a variety of signals, especially those related to immune activation. IFN-γ Activators are compounds or agents that specifically target and modulate the activity of interferon-gamma (IFN-γ). Interferon-gamma is a cytokine, which is a type of signaling molecule that plays a pivotal role in the immune system's response to infections and various pathogenic threats. It is primarily produced by activated T cells, natural killer cells, and other immune cells in response to the presence of viruses, bacteria, or tumor cells. IFN-γ is a critical component of the body's innate and adaptive immune defenses, and it exerts a wide range of immunomodulatory functions.
The activation of IFN-γ is central to the immune response, as it can induce the expression of several hundred genes involved in various aspects of immunity and inflammation. These genes help to enhance the activity of macrophages, which are immune cells responsible for phagocytosis (ingesting and destroying pathogens), and they promote the activity of T cells, which are vital for the adaptive immune response. IFN-γ also plays a crucial role in regulating the adaptive immune system by influencing the differentiation of T cells into specific subtypes and aiding in the antibody production by B cells. Furthermore, it can have antiviral effects, inhibiting viral replication within infected cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS activates Toll-like receptor 4 (TLR4) signaling, leading to IFN-γ induction. | ||||||
Polyinosinic-polycytidylic acid potassium salt | 31852-29-6 | sc-202767 | 5 mg | $198.00 | ||
Poly I:C interacts with Toll-like receptor 3 (TLR3), resulting in the activation of downstream signaling pathways and subsequent IFN-γ expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), leading to IFN-γ upregulation. | ||||||
Zymosan A from Saccharomyces cerevisiae | 58856-93-2 | sc-258367 sc-258367A | 250 mg 1 g | $90.00 $222.00 | 2 | |
Zymosan activates Toll-like receptor 2 (TLR2) signaling, resulting in IFN-γ upregulation. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod activates Toll-like receptor 7 (TLR7), promoting IFN-γ production. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
While primarily an immunosuppressant, in certain contexts, it might paradoxically increase IFN-γ production. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $119.00 $364.00 $947.00 | 17 | |
A mitogen that stimulates T cell activation and proliferation, leading to increased IFN-γ production. | ||||||
Levamisole Hydrochloride | 16595-80-5 | sc-205730 sc-205730A | 5 g 10 g | $43.00 $68.00 | 18 | |
Enhances immune response by stimulating T cells and increasing IFN-γ production. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
An immune response modifier similar to imiquimod; activates TLR7 and TLR8 to induce IFN-γ production. | ||||||