PMA CAS: 16561-29-8
MF: C36H56O8
MW: 616.83

PMA (CAS 16561-29-8)

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备用名: PMA is also known as Phorbol-12-Myristate-13-Acetate.
应用; PMA is a reversible and highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations.
CAS号码: 16561-29-8
纯度: ≥95%
分子量: 616.83
分子式: C36H56O8
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. PMA is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA′s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC. PMA activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. PMA has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells. PMA is also known as Phorbol-12-Myristate-13-Acetate, TPA, 12-O-Tetradecanoylphorbol-13-acetate, PKC Activator I, and tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester.


参考文献

1. Castagna, M., et al. 1982. J. Biol. Chem. 257: 7847-7851. PMID: 7085651

2. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. U.S.A. 82: 2774-2778. PMID: 2859591

3. Saltis, J., et al. 1991. J. Biol. Chem. 266: 261-267. PMID: 1985898

4. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73: 2011-2015. PMID: 1474079

5. Oishi, K. and Yamaguchi, M. 1994. J. Cell. Biochem. 55: 168-172. PMID: 8089192

6. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. U.S.A. 92: 8443-8447. PMID: 7545303

7. Powell, D.J., et al. 2003. Mol. Cell. Biol. 23: 7794-7808. PMID: 14560023

8. Saraiva, L., et al. 2004. Eur. J. Pharmacol. 491: 101-110. PMID: 15140626

9. Shimura, C., et al. 2010. Am. J. Pathol. 176: 227-237. PMID: 20008150

用法 :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month.
物理状态 :
Solid
溶解度 :
Soluble in DMSO (25 mg/ml), 100%ethanol (25 mg/ml), acetone, ether, DMF, methanol, and chloroform. Insoluble in water, and aqueous buffers.
保存 :
Store at -20° C
熔点 :
50-70° C
沸点 :
~698.10° C at 760 mmHg (Predicted)
密度 :
1.17 g/cm3 (Predicted)
折射率 :
n20D 1.55 (Predicted)
光学活性 :
α24D +49, c = 1 in dioxane
Ki 数据 :
PKC: Ki= 2.6 nM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
QH4377000
PubChem CID :
默克索引 :
14: 7332
MDL 号码 :
MFCD00036736
Beilstein 注册 :
2407201
SMILES :

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PMID: # 34192597  Pazoki, H.|Mohammad Rahimi, H.|Mirjalali, H.|Niyyati, M.|Mosaffa, N.|Seyed Tabaei, SJ.|Shahrokh, S.|Asadzadeh Aghdaei, H.|Zali, MR.| et al. 2021. Microb Pathog. 158: 105072.

PMID: # 34044082  Pap, N.|Reshamwala, D.|Korpinen, R.|Kilpeläinen, P.|Fidelis, M.|Furtado, MM.|Sant'Ana, AS.|Wen, M.|Zhang, L.|Hellström, J.|Marnilla, P.|Mattila, P.|Sarjala, T.|Yang, B.|Lima, ADS.|Azevedo, L.|Marjomäki, V.|Granato, D.| et al. 2021. Food Chem Toxicol. 153: 112284.

PMID: # 33558623  Malek, N.|Michrowska, A.|Mazurkiewicz, E.|Mrówczyńska, E.|Mackiewicz, P.|Mazur, AJ.| et al. 2021. Sci Rep. 11: 3329.

PMID: # 34063504  Damato, M.|Cardon, T.|Wisztorski, M.|Fournier, I.|Pieragostino, D.|Cicalini, I.|Salzet, M.|Vergara, D.|Maffia, M.| et al. 2021. Int J Mol Sci. 22:

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PMID: # 34161786  Liang, D.|Cheloha, RW.|Watanabe, T.|Gardella, TJ.|Baskin, JM.| et al. 2021. Cell Chem Biol.

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引用1 - 1092
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