Id1 Antibody (B-1): sc-133103
- Id1 Antibody (B-1) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 118-159 at the C-terminus of Id1 of mouse origin
- recommended for detection of Id1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
- TransCruz reagent for ChIP application (sc-133103 X, 200 µg/0.1 ml)
- See Id1 (B-8): sc-133104 for Id1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Id1 Antibody (B-1) for WB and IHC(P) applications. These reagents are now offered in bundles with Id1 Antibody (B-1) (see ordering information below).
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Id1 Antibody (B-1) is a mouse monoclonal IgG2a kappa light chain antibody designed to target the C-terminal epitope (amino acids 118-159) of the mouse Id1 protein. Inhibitor of DNA binding 1 (Id1), also called Idb1, bHLHb24, and D2Wsu140e, is a crucial member of the Inhibitor of DNA binding (Id) family of basic helix-loop-helix (bHLH) proteins, which play a significant role in regulating cellular processes such as differentiation, proliferation, and angiogenesis. By dimerizing with class A and B HLH proteins, Id1 effectively inhibits their ability to bind DNA, thereby negatively regulating the transcriptional activity of these proteins. This inhibition is essential for controlling muscle-specific gene expression, as Id1 prevents the binding of transcription factors like E12 and Myo D, which are necessary for muscle cell differentiation. Under conditions that promote muscle differentiation, Id1 levels decrease, allowing these transcription factors to activate myogenic genes and drive the differentiation process forward. Additionally, Id1 is involved in cell cycle regulation, where expression is tightly controlled by growth factor signals. Reduction of Id1 mRNA levels has been shown to delay the reentry of arrested cells into the cell cycle following growth factor stimulation, highlighting Id1′s importance in cell proliferation and cancer research. Anti-Id1 antibody (B-1) exhibits broad species reactivity, effectively recognizing Id1 proteins from mouse, rat, and human origins, as well as additional species including canine. Id1 (B-1) antibody is versatile in multiple applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA), making Id1 (B-1) monoclonal antibody an invaluable tool for researchers studying the intricate roles of Id1 in various biological contexts. By providing detailed insights into Id1′s function and regulation, anti-Id1 antibody (B-1) supports advancements in understanding muscle differentiation, cell cycle control, and the molecular mechanisms underlying various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Id1 Antibody (B-1) | sc-133103 | 200 µg/ml | $316.00 | |||
Id1 Antibody (B-1): m-IgG Fc BP-HRP Bundle | sc-537342 | 200 µg Ab; 10 µg BP | $354.00 | |||
Id1 Antibody (B-1): m-IgGκ BP-HRP Bundle | sc-534584 | 200 µg Ab; 40 µg BP | $354.00 | |||
Id1 Antibody (B-1): m-IgG2a BP-HRP Bundle | sc-547986 | 200 µg Ab; 10 µg BP | $354.00 | |||
Id1 (B-1) Neutralizing Peptide | sc-133103 P | 100 µg/0.5 ml | $68.00 | |||
Id1 Antibody (B-1) X | sc-133103 X | 200 µg/0.1 ml | $316.00 |