Huntingtin Antibody (8A4): sc-47759

Huntingtin Antibody (8A4) is a mouse monoclonal IgG1 antibody that detects Huntingtin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Huntingtin is a crucial protein that plays a significant role in neuronal function and survival, and proper functioning is vital for maintaining cellular health. Huntingtin (8A4) antibody targets proteins primarily located in the cytoplasm and nucleus, where Huntingtin is involved in various cellular processes, including intracellular transport and transcriptional regulation. Huntingtin′s nuclear localization is essential for mediating gene expression critical for neuronal health. Mutations in the Huntingtin gene, particularly those leading to an expanded polyglutamine repeat, disrupt normal function and localization, contributing to Huntington′s disease pathogenesis. Anti-Huntingtin antibody (8A4) helps researchers study interactions with several key proteins, including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), and HIP1, which are involved in cellular signaling and metabolic pathways. Huntingtin monoclonal antibody (8A4) serves as an invaluable tool for studying molecular mechanisms underlying Huntington′s disease and broader implications in neurodegenerative disorders.

The preferred Huntingtin antibody is Huntingtin Antibody (3E10): sc-47757.