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Huntingtin Antibody (3E10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Huntingtin (HTT) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-HTT antibody (3E10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HTT (3E10) monoclonal antibody plays a crucial role in studying neuronal function, intracellular transport, transcriptional regulation, and synaptic function. HTT′s proper functioning is vital for maintaining neuronal health, and mutations in HTT, particularly those leading to an expanded polyglutamine region, are associated with Huntington′s disease. The abnormal polyglutamine expansion results in a toxic gain of function, leading to neurodegeneration through mechanisms that may involve altered interactions with other cellular proteins. Notably, HTT interacts with several key proteins, including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), and HIP1, which are implicated in various cellular processes. Understanding these interactions is essential for elucidating the pathophysiology of Huntington′s disease and developing potential therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Huntingtin Antibody (3E10) | sc-47757 | 200 µg/ml | $316.00 | |||
Huntingtin Antibody (3E10) AC | sc-47757 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Huntingtin Antibody (3E10) HRP | sc-47757 HRP | 200 µg/ml | $316.00 | |||
Huntingtin Antibody (3E10) FITC | sc-47757 FITC | 200 µg/ml | $330.00 | |||
Huntingtin Antibody (3E10) PE | sc-47757 PE | 200 µg/ml | $343.00 | |||
Huntingtin Antibody (3E10) Alexa Fluor® 488 | sc-47757 AF488 | 200 µg/ml | $357.00 | |||
Huntingtin Antibody (3E10) Alexa Fluor® 546 | sc-47757 AF546 | 200 µg/ml | $357.00 | |||
Huntingtin Antibody (3E10) Alexa Fluor® 594 | sc-47757 AF594 | 200 µg/ml | $357.00 | |||
Huntingtin Antibody (3E10) Alexa Fluor® 647 | sc-47757 AF647 | 200 µg/ml | $357.00 | |||
Huntingtin Antibody (3E10) Alexa Fluor® 680 | sc-47757 AF680 | 200 µg/ml | $357.00 | |||
Huntingtin Antibody (3E10) Alexa Fluor® 790 | sc-47757 AF790 | 200 µg/ml | $357.00 |