Huntingtin Antibody (4E10): sc-47758

Huntingtin Antibody (4E10) is a mouse monoclonal IgG1 antibody that detects Huntingtin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Huntingtin is a crucial protein that plays a significant role in neuronal function and survival, and proper functioning is vital for maintaining cellular health. Huntingtin is primarily located in the cytoplasm and nucleus, where Huntingtin is involved in various cellular processes, including intracellular transport and transcriptional regulation. This localization is particularly important because Huntingtin can interact with other cellular components, facilitating essential signaling pathways and cellular responses. Notably, Huntingtin interacts with several key proteins, including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), and HIP1, which are involved in neuroprotective mechanisms and cellular metabolism. Dysregulation of these interactions, especially in the context of expanded polyglutamine repeats associated with Huntington′s disease, can lead to neurodegeneration and characteristic symptoms of the disorder. Anti-Huntingtin antibody (4E10) is an invaluable tool for researchers studying molecular mechanisms underlying Huntington′s disease and related neurodegenerative conditions.

The preferred Huntingtin antibody is Huntingtin Antibody (3E10): sc-47757.