HSP 105 Antibody (B-7): sc-74550

HSP 105 Antibody (B-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects HSP 105 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HSP 105 antibody (B-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HSP 105, a member of the heat shock protein family, plays a crucial role in cellular stress responses, particularly in protein stabilization under stress conditions. HSP 105 is primarily localized in germ cells, where HSP 105 assists in proper folding and stabilization of proteins, including tumor suppressor p53. This interaction helps prevent premature induction of apoptosis in germ cells, ensuring proper cell survival and function during stress. Unique structural features of HSP 105, including oligomer formation capability, enhance chaperone activity, making HSP 105 essential for maintaining cellular homeostasis. HSP 105 (B-7) antibody enables researchers to gain valuable insights into cellular stress response mechanisms and molecular chaperone roles in various biological processes.

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HSP 105 Antibody (B-7) References:

1. Germ cell-specific heat shock protein 105 binds to p53 in a temperature-sensitive manner in rat testis.  |  Kumagai, J., et al. 2000. Eur J Biochem. 267: 3073-8. PMID: 10806408
2. Effects of low culture temperature on the induction of hsp70 mRNA and the accumulation of hsp70 and hsp105 in mouse FM3A cells.  |  Hatayama, T., et al. 1992. J Biochem. 111: 484-90. PMID: 1618738
3. Common antigenicity of mouse 42 degrees C-specific heat-shock protein with mouse HSP 105.  |  Honda, K., et al. 1989. Biochem Biophys Res Commun. 160: 60-6. PMID: 2469422
4. HSP105 recruits protein phosphatase 2A to dephosphorylate β-catenin.  |  Yu, N., et al. 2015. Mol Cell Biol. 35: 1390-400. PMID: 25645927
5. Requirement of Hsp105 in CoCl2-induced HIF-1α accumulation and transcriptional activation.  |  Mikami, H., et al. 2017. Exp Cell Res. 352: 225-233. PMID: 28185835
6. Functional differences between Hsp105/110 family proteins in cell proliferation, cell division, and drug sensitivity.  |  Teshima, H., et al. 2021. J Cell Biochem. 122: 1958-1967. PMID: 34617313
7. HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.  |  Chen, KJ., et al. 2021. PLoS One. 16: e0258053. PMID: 34618840
8. HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway.  |  Jia, M., et al. 2023. Am J Cancer Res. 13: 3013-3026. PMID: 37559974
9. Dynamics of the chaperonin ATPase cycle: implications for facilitated protein folding.  |  Todd, MJ., et al. 1994. Science. 265: 659-66. PMID: 7913555
10. Role of the major heat shock proteins as molecular chaperones.  |  Georgopoulos, C. and Welch, WJ. 1993. Annu Rev Cell Biol. 9: 601-34. PMID: 8280473
11. Cloning and expression of murine high molecular mass heat shock proteins, HSP105.  |  Yasuda, K., et al. 1995. J Biol Chem. 270: 29718-23. PMID: 8530361
12. Induction of Apg-1, a member of the heat shock protein 110 family, following transient forebrain ischemia in the rat brain.  |  Xue, JH., et al. 1998. Biochem Biophys Res Commun. 247: 796-801. PMID: 9647773

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSP 105 Antibody (B-7) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-HSP 105 Antibody (B-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSP 105 Antibody (B-7) Specifications

Alternate Product Name: HSPH1

Product Clone Name: B-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 187-512

Epitope Target: HSP 105

Epitope Species: mouse

Product Reactivity/Detection: HSP 105

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for HSP 105 Antibody (B-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin